摘要
目的:探讨气管镜下消融术结合图像引导放疗对阻塞性非小细胞肺癌(NSCLC)的疗效及相关因子的影响。方法:选取79例支气管阻塞性NSCLC患者为研究对象,按照治疗方式不同分为对照组(n=37)和观察组(n=42)。对照组行图像引导放射治疗,观察组行气管镜下消融术结合图像引导放射治疗;比较两组患者肿瘤客观缓解率、症状改善、残瘤复发因子水平、不良反应发生率及对治疗的依从性。结果:治疗后,观察组患者肿瘤客观缓解率及满意度高于对照组,支气管阻塞症状(咳嗽、气短、呼吸困难)发生率、基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)水平低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率及治疗费用比较,差异无统计学意义(P>0.05)。结论:在支气管阻塞性NSCLC患者中,气管镜下消融术结合图像引导放射治疗,可有效提高患者肿瘤客观缓解率,改善其支气管阻塞症状,降低残瘤复发因子水平,且不增加患者不良反应,依从性好,值得临床推广使用。
Objective:To investigate the effect of bronchoscope ablation combined with image-guided radiotherapy on obstructive NSCLC and related factors.Methods:79 patients with bronchial obstructive NSCLC were selected as the study subjects.According to the treatment methods,they were divided into control group(n=37)and observation group(n=42).The control group was treated with image-guided radiotherapy,and the observation group was treated with tracheoscopic tumor ablation combined with image-guided radiotherapy,The objective remission rate,symptom improvement,residual tumor recurrence factor,adverse reactions and compliance of the two groups were analyzed.Results:After treatment,the objective remission rate and satisfaction of the observation group were significantly higher than those of the control group,the incidence of bronchial obstruction symptoms(cough,shortness of breath,dyspnea),the levels of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in adverse reactions and treatment costs between the two groups(P>0.05).Conclusion:In patients with bronchial obstructive NSCLC,bronchoscopic ablation combined with image-guided radiotherapy can effectively improve the objective tumor remission rate,improve the symptoms of bronchial obstruction,reduce the level of residual tumor recurrence factor,without increasing adverse reactions of patients,with good compliance,which is worthy of clinical application.
作者
赵新
韩鲁军
张淼
张燕
许会军
陈晓芳
马骖
ZHAO Xin;HAN Lu-jun;ZHANG Miao;ZHANG Yan;XU Hui-jun;CHEN Xiao-fang;MA Gu(Department of Oncology,Shijiazhuang People's Hospital,Shijiazhuang 050000,Hebei,China;Department of Radiotherapy,Shijiazhuang People's Hospital,Shijiazhuang 050000,Hebei,China)
出处
《川北医学院学报》
CAS
2021年第5期573-576,共4页
Journal of North Sichuan Medical College
基金
河北省重点研发计划自筹项目(172777135)。
