摘要
目的探讨血中性粒细胞明胶酶相关性载脂蛋白(NGAL)、肝型脂肪酸结合蛋白(L-FABP)、胱抑素C(CysC)早期预测绝经期妇女经皮冠脉介入(PCI)术后对比剂肾病(CIN)。方法选择2018年6月至2020年9月我院收治的绝经期妇女PCI术后CIN患者80例为试验组,同期在我院行PCI术治疗且术后无CIN发生的绝经期妇女80例为对照组。对比两组NGAL、L-FABP、CysC差异,分析NGAL、L-FABP、CysC早期预测绝经期妇女PCI术后CIN价值。结果试验组NGAL、L-FABP、CysC水平高于对照组,差异有统计学意义(P<0.05);NGAL早期预测绝经期妇女PCI术后CIN的曲线下面积(AUC)为0.919,敏感度和特异度分别为88.96%、87.01%;L-FABP早期预测绝经期妇女PCI术后CIN的AUC为0.851,敏感度和特异度分别为85.95%、88.11%;CysC早期预测绝经期妇女PCI术后CIN的AUC为0.922,敏感度和特异度分别为83.24%、94.68%。结论血NGAL、L-FABP、CysC均是早期预测绝经期妇女PCI术后CIN的有效指标,可作为诊断CIN的“肌钙蛋白”。
Objective To explore the value of serum neutrophil gelatinase-associated apolipoprotein(NGAL),liver fatty acid binding protein(L-FABP)and cystatin C(CysC)in the early prediction of contrast-induced nephropathy(CIN)for menopausal women after percutaneous coronary intervention(PCI).Methods A total of 80 menopausal women with CIN after PCI in our hospital from June 2018 to September 2020 were selected as the experimental group,while 80 menopausal women without CIN after PCI in our hospital at the same time were selected as the control group.The differences of NGAL,L-FABP and CysC between the two groups were compared,and the value of NGAL,L-FABP and CysC in the early prediction of CIN of menopausal women after PCI was analyzed.Results The levels of NGAL,L-FABP and CysC were higher in the experimental group than those in the control group,and the differences were statistically significant(P<0.05).The area under curve(AUC)of NGAL for early prediction of CIN in menopausal women after PCI was 0.919,and the sensitivity and specificity were 88.96%and 87.01%,respectively.The AUC of L-FABP for early prediction of CIN in menopausal women after PCI was 0.851,and the sensitivity and specificity were 85.95%and 88.11%,respectively.The AUC of CysC for early prediction of CIN in menopausal women after PCI was 0.922,and the sensitivity and specificity of 83.24%and 94.68%,respectively.Conclusion Serum NGAL,L-FABP and CysC are all effective indicators for early prediction of CIN in menopausal women after PCI,and can be used as“troponin”for diagnosis of CIN.
作者
王小明
彭四萍
廖洁
WANG Xiaoming;PENG Siping;LIAO Jie(Medical Laboratory,Pingxiang People′s Hospital in Jiangxi Province,Pingxiang 337000,China;Department of Cardiovascular Internal Medicine,Pingxiang People′s Hospital in Jiangxi Province,Pingxiang 337000,China)
出处
《中国现代医生》
2021年第13期21-24,共4页
China Modern Doctor
基金
江西省卫生计生委科技计划项目(20197278)。
关键词
绝经期妇女
对比剂肾病
经皮冠脉介入
中性粒细胞明胶酶相关性载脂蛋白
胱抑素C
肝型脂肪酸结合蛋白
Menopausal women
Contrast agent nephropathy
Percutaneous coronary intervention
Neutrophil gelatinase-associated apolipoprotein
Cystatin C
Liver fatty acid binding protein
