摘要
目的通过对该院肝衰竭合并真菌感染患者资料进行回顾性分析,为临床治疗提供帮助。方法以该院感染科2015年1月至2019年12月住院诊断为肝衰竭合并真菌感染的65例患者为研究组,另选取同期住院的65例肝衰竭患者作为对照组。采用SPSS26.0软件对两组患者临床资料进行统计分析。结果研究组共培养出菌株19株,其中白念珠菌7株(36.8%),光滑念珠菌2株(10.5%),热带念珠菌2株(10.5%),烟曲霉菌3株(15.8%)。肝衰竭合并真菌感染部位以呼吸道为主,为40.0%;其次是消化道,为30.8%。多因素logistic回归分析发现,使用广谱抗菌药、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶在两组间比较差异有统计学意义(P<0.05)。结论肝衰竭患者使用广谱抗菌药易感染真菌。
Objective To provide help for clinical treatment by retrospectively analyzing the data of the patients with liver failure complicating fungal infection in this hospital.Methods Sixty-five patients with liver failure complicating fungal infection from January 2015 to December 2019 in the partment of Infectious Diseases of the hospital served as the study group,and 65 cases of liver failure hospitalized in the same period as the control group.The clinical data of the two groups were statistically analyzed by SPSS26.0 software.Results A total of 19 strains were cultured in the study group,including 7 strains of Candida albicans(36.8%),2 strains of Candida smooth(10.5%),2 strains of Candida tropicalis(10.5%)and 3 strains of Aspergillus fumigatus(15.8%).The site of liver failure complicated with fungal infection was mainly the respiratory tract(40.0%),followed by the digestive tract(30.8%).The multivariate logistic regression analysis showed that there were significant difference in the use of broad-spectrumantibiitics and ALT and AST among the two groups(P<0.05).Conclusion Using of broad-spectrum antimicrobials in the patients with liver failure is susceptible to fungal infection.
作者
蔡秋红
崔琦
王余彦
罗红春
曾爱中
CAI Qiuhong;CUI Qi;WANG Yuyan;LUO Hongchun;ZENG Aizhong(Department of Infectious Disease,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《重庆医学》
CAS
2021年第11期1821-1825,共5页
Chongqing medicine
基金
国家自然科学基金项目(81502117)。
关键词
肝衰竭
真菌感染
临床特点
危险因素
liver failure
fungal infection
clinical characteristics
risk factors
