摘要
中毒性休克毒素-1(TSST-1)是噬菌体Ⅰ群金黄色葡萄球菌产生的外毒素,属于致热原性超抗原家族,其感染机体后可引起发热、脱屑型皮疹及休克,造成多器官功能紊乱,甚至引起中毒性休克综合征,对患者的健康构成严重威胁。TSST-1的研究在金黄色葡萄球菌感染的临床诊断、治疗及预后判断方面都具有重要价值。该文概述了TSST-1的表达调控、致病机制以及与临床疾病的相关性,并对未来靶向TSST-1的抗毒力治疗进行了展望。
Toxic shock toxin-1(TSST-1)is an exotoxin produced by bacteriophage groupⅠStaphylococcus aureus,belonging to the family of pyrogenic superantigens.After it infects the body,it can cause fever,desquamative rash,shock,multiple organ dysfunction,and even cause toxic shock syndrome,posing a serious threat to the patient′s health.The study of TSST-1 is of great value in the clinical diagnosis,treatment and prognosis evaluation of Staphylococcus aureus infection.This article summarizes the expression regulation of TSST-1,its pathogenic mechanism,and its correlation with clinical diseases,and prospects for antiviral treatments by targeting TSST-1 in the future.
作者
褚敏君(综述)
麻明彪
杜廷义(审校)
CHU Minjun;MA Mingbiao;DU Tingyi(Department of Clinical Laboratory,Children′s Hospital of Kunming Medical University,Kunming,Yunnan 650228,China)
出处
《国际检验医学杂志》
CAS
2021年第12期1521-1524,1536,共5页
International Journal of Laboratory Medicine
基金
云南省教育厅科学研究基金项目(NO.2020J0229、NO.2020J0224)
昆明市卫生科技人才培养项目暨“十百千”工程培养计划(NO.2016-sw-20、NO.2020-SW(后备)-109)。
