摘要
目的探究有氧运动对慢性阻塞性肺疾病稳定期患者外周血T、B淋巴细胞亚群及肺循环、体循环的影响。方法选取慢性阻塞性肺疾病稳定期患者98例为研究对象,将其随机分为对照组(常规干预组)和观察组(常规干预联合有氧运动组),每组49例。比较两组干预前后不同时间的外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)及CD8^(+))、B淋巴细胞亚群(CD19^(+)、CD5^(+)及CD20^(+))及肺循环指标[平均肺动脉压(mean pulmonary arterial pressure,mPAP)及肺血管阻力(pulmonary vascular resistance,PVR)]、体循环指标[平均体循环压(mean systemic arterial pressure,mSAP)及体循环阻力(peripheral vascular resistance,SVR)]。结果干预后6周及12周观察组的外周血T淋巴细胞亚群、B淋巴细胞亚群、肺循环指标及体循环指标SVR均显著优于对照组,差异有统计学意义(P<0.05)。结论有氧运动对慢性阻塞性肺疾病稳定期患者外周血T、B淋巴细胞亚群及肺循环、体循环的影响相对较好,在本类患者稳定期的应用价值较高。
Objective To investigate the effect of aerobic exercise on peripheral blood T and B lymphocyte subsets,pulmonary circulation and systemic circulation of patients with chronic obstructive pulmonary disease(COPD)at stable stage.Methods A total of 98 patients with COPD at stable stage treated were selected as the research subjects,and they were randomly divided into control group(routine intervention group)and observation group(routine intervention and aerobic exercise group),with 49 cases in each group.Then the peripheral blood T lymphocyte subsets(CD3^(+),CD4^(+)and CD8^(+))and B lymphocyte subsets(CD19^(+),CD5^(+)and CD20^(+)),pulmonary circulation indexes(mean pulmonary arterial pressure and pulmonary vascular resistance)and systemic circulation indexes(mean systemic arterial pressure and peripheral vascular resistance)of two groups at different time points before and after the intervention were compared.Results The peripheral blood T lymphocyte subsets,peripheral blood B lymphocyte subset,pulmonary circulation indexes and systemic circulation indexes SVR of observation group at 6 and 12 weeks after the intervention were all significantly better than those of control group,and there were statistically significant differences(P<0.05).Conclusion The effect of aerobic exercise on peripheral blood T and B lymphocyte subsets,pulmonary circulation and systemic circulation of patients with COPD at stable stage is relatively better,and it has a higher application value in the patients with COPD at stable stage.
作者
张梓楠
厉坤鹏
陈浩
肖琳
冯莹
ZHANG Zi-nan;LI Kun-peng;CHEN Hao;XIAO Lin;FENG Ying(Department of Rehabilitation, the Second Rehabilitation Hospital of Shanghai City, Shanghai 200431, China;Department of Respiratory Diseases, Central Hospital of Jing′an District, Shanghai 200040, China)
出处
《河北医科大学学报》
CAS
2021年第6期661-664,共4页
Journal of Hebei Medical University
基金
上海市卫生和计划生育委员会科研课题计划(201740184)。
