摘要
目的:评价防己黄芪汤联合西医治疗儿童肾病综合征的效果。方法:收集肾病综合征患儿60例,按随机数字表法分为治疗组和对照组各30例。对照组口服泼尼松治疗并对症处理,治疗组在此基础之上予以防己黄芪汤治疗,治疗共维持3个月。评价两组临床疗效,统计治疗前后两组24 h蛋白尿、肌酐(Creatinine,Cr)、尿素氮(Blood Urea Nitrogen,BUN)、尿酸(Uric Acid,UA)和尿微量白蛋白(Micro-albumin,ALB)的含量。记录治疗后两组出现不良反应的情况并比较。结果:治疗组总有效率显著高于对照组(P=0.043)。治疗后治疗组24 h蛋白尿、肌酐、尿素氮、尿酸和尿微量白蛋白显著下降(P<0.05),对照组24 h蛋白尿、肌酐、尿酸和ALB也显著下降(P<0.05)。治疗后治疗组24 h蛋白尿、肌酐、尿素氮、尿酸和ALB均显著低于对照组,差异有统计学意义(P<0.05)。治疗后对照组三酰甘油(Triglyceride,TG)和总胆固醇(Total Cholesterol,TC)显著降低(P<0.05),治疗组中的TG和TC显著降低(P<0.05),且治疗组各指标的水平显著低于对照组(P<0.05)。治疗后两组均出现少量皮下瘀斑和纳差等不良症状,治疗组总不良反应率低于对照组,两组差异无统计学意义(P=0.542)。结论:防己黄芪汤联合西医干预治疗儿童肾病综合征疗效优于单纯西药治疗,且不增加不良反应。
Objective:To evaluate the effects of the Fangji Huangqi decoction(防己黄芪汤)plus Western medicine on nephrotic syndrome in children.Methods:60 cases were divided into the treatment group and the control group according to the random number table method,30 cases for each.The control group was treated with oral prednisone,and the treatment group was treated with the Fangji Huangqi decoction more.The treatment was maintained for 3 months.Results:The total efficiency in the treatment group was significantly higher than that in the control group(P=0.043).After treatment,24 h proteinuria,Cr,BUN and ALB in the control group were decreased significantly(P<0.05),and the 24 h proteinuria,Cr,BUN,UA and ALB in the treatment group were significantly lower than those in the control group,with a statistically significant difference(P<0.05).After treatment,TG and TC in the control group were significantly reduced(P<0.05).TG,TC and PT in the treatment group were also significantly reduced(P<0.05),and the level of each index in the treatment group was significantly lower than the control group(P<0.05).After treatment,both groups showed a small amount of adverse symptoms,such as subcutaneous ecchymosis and anorexia,etc.The total adverse reaction in the treatment group was lower than the control group,and the difference between the groups was not statistically significant(P=0.542).Conclusion:The Fangji Huangqi decoction plus Western medicine is better than Western medicine alone in treating nephrotic syndrome in children,and does not increase adverse reactions.
出处
《中医临床研究》
2021年第10期81-83,共3页
Clinical Journal Of Chinese Medicine
关键词
儿童肾病综合征
防己黄芪汤
临床疗效
不良反应
Nephrotic syndrome in children
The Fangji Huangqi decoction
Clinical efficacy
Adverse reactions
