摘要
目的:研究胃癌组织中DAB2相互作用蛋白(DAB2IP)和锌指蛋白(Snail)的表达,并分析两者与患者临床病理资料及预后的关系。方法:收集2016年1月-2017年12月于我院住院治疗的胃癌患者82例,采用免疫组化技术检测胃癌和癌旁正常组织中DAB2IP和Snail的阳性表达率,分析两者的相关性及与临床病理资料之间的关系。随访时间为3年,采用Kaplan-Meier检验分析DAB2IP和Snail的表达水平与胃癌患者预后关系。结果:胃癌组织中DAB2IP的阳性表达率明显低于癌旁正常组织,而Snail的阳性表达率则高于癌旁正常组织(P<0.05)。胃癌组织中DAB2IP和Snail的表达呈负相关(r=-0.747,P=0.000)。胃癌组织中DAB2IP和Snail阳性表达率与肿瘤TNM分期、细胞分化程度及淋巴转移有关(P<0.05)。DAB2IP表达阳性患者3年生存率高于阴性患者,Snail表达阳性患者3年生存率低于阴性患者(P<0.05)。结论:胃癌组织中DAB2IP阳性表达率下降,Snail阳性表达率升高,与肿瘤TNM分期、细胞分化程度及淋巴转移有关。两者均参与胃癌的发生发展过程,有望成为胃癌诊断及治疗的新的生物学靶点。
Objective: To study the expression of DAB2 interacting protein(DAB2 IP) and zinc finger protein(Snail) in gastric cancer, and analyze the relationship between the two and the clinicopathological data and prognosis of patients. Methods: A total of 82 gastric cancer patients who were hospitalized in our hospital from From January 2016 to December 2017 were collected. Immunohistochemical technique was used to detect the positive expression rates of DAB2 IP and Snail in gastric cancer and normal tissues adjacent to the cancer, and to analyze the correlation between the two and the relationship with clinical pathological data. The follow-up period was 3 years. Kaplan-Meier test was used to analyze the relationship between the expression levels of DAB2 IP and Snail and the prognosis of gastric cancer patients. Results: The expression of DAB2 IP in gastric cancer was significantly lower than that in normal adjacent to cancer, while the expression of Snail was higher than that in normal adjacent to cancer. The expression of DAB2 IP and Snail was negatively correlated in gastric cancer(r=-0.747, P=0.000). The expressions of DAB2 IP and Snail in gastric cancer were related to tumor TNM stage, cell differentiation and lymphatic metastasis(P<0.05), but not to age, gender and tumor diameter(P>0.05). The 3-year survival rate of DAB2 IP positive patients was higher than that of negative patients, and the 3-year survival rate of Snail positive patients was lower than that of negative patients(P<0.05). Conclusion: The expression of DAB2 IP decreased and the expression of Snail increased in gastric cancer, which was related to tumor TNM stage, cell differentiation and lymphatic metastasis. Both are involved in the occurrence and development of gastric cancer, and are expected to become a new biological target for the diagnosis and treatment of gastric cancer.
作者
秦虹
宋金霞
底玮
李宏
QIN Hong;SONG Jinxia;DI wei;LI Hong(Department of Oncology,Qingdao Eighth People’s Hospital,Qingdao,266000,China;Department of Pathology,the Affiliated Hospital of Qingdao University)
出处
《中国中西医结合消化杂志》
CAS
2021年第6期411-415,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
山东省科技发展计划项目(No:2017ZRC10070)。
