摘要
目的探讨卵巢恶性肿瘤患者发生静脉血栓栓塞症(VTE)的相关因素。方法收集65例发生VTE的卵巢恶性肿瘤患者的病历资料,采用修改后的Caprini风险评估量表评估患者的VTE发生风险,并分析卵巢恶性肿瘤患者发生VTE的危险因素。结果根据修改后的Caprini风险评估量表进行评分,65例患者中,高危16例(24.62%),极高危47例(72.31%)。高级别浆液性癌33例,低分化癌16例,共占75.38%。国际妇产科联盟(FIGO)分期Ⅲ-Ⅳ期43例(66.15%),腹腔积液量﹥1000 ml 18例(27.69%)。血栓发生于术前35例(53.85%),血栓发生于术后11例(16.92%),血栓发生于化疗中5例(7.69%),血栓发生于随访期14例(21.54%)。62例患者置入中心静脉导管,其中,发生静脉血栓时57例(91.94%)患者已拔除导管,另5例(8.06%)患者静脉血栓发生于带管时期。9例(13.85%)患者伴有盆腔淋巴囊肿。结论修改后的Caprini风险评估量表中,高危和极高危卵巢恶性肿瘤患者易发生VTE,该量表有助于临床早期识别VTE高危患者。组织学分化程度和临床分期与卵巢恶性肿瘤患者发生VTE有关。
Objective To investigate the related factors of venous thromboembolism(VTE)in patients with ovarian malignant tumor.Method Medical records of 65 patients with ovarian malignant tumor who developed VTE were collected.Modified Caprini risk assessment scale was used to evaluate the risk of VTE,and the risk factors for VTE were analyzed.Result There were 16 high risk cases(24.62%)and 47 very high risk cases(72.31%)in 65 patients based on the modified Caprini risk assessment scale.There were 33 cases of high-grade serous carcinoma and 16 cases of poorly differentiated carcinoma,accounting for 75.38%.There were 43 stageⅢ-Ⅳcases(66.15%)according to the International Federation of Gynecology and Obstetrics(FIGO)staging,18 cases(27.69%)with abdominal fluid volume>1000 ml.Thrombosis occurred before surgery in 35 cases(53.85%),11 cases(16.92%)after surgery,5 cases(7.69%)during chemotherapy,and 14 cases(21.54%)during follow-up.Central venous catheters were inserted in 62 patients,of which 57 patients(91.94%)had the catheter removed when venous thrombosis occurred,and 5 patients(8.06%)had venous thrombosis during the catheter period.9 patients(13.85%)had concurrent pelvic lymphocyst.Conclusion In the modified Caprini risk assessment scale,high-risk and very high-risk ovarian malignant tumor patients are prone to occurrence of VTE,and the scale is helpful for early clinical identification of high-risk patients with VTE.Degree of histological differentiation and clinical stage are associated with VTE in patients with ovarian malignant tumor.
作者
闫华
邹存华
郝娟
张玉英
冯富忠
赵淑萍
YAN Hua;ZOU Cunhua;HAO Juan;ZHANG Yuying;FENG Fuzhong;ZHAO Shuping(Department of Gynecology,Qingdao Women and Children’s Hospital,Qingdao University,Qingdao 266034,Shandong,China;Department of Gynecology,Linyi Central Hospital,Linyi 276400,Shandong,China)
出处
《癌症进展》
2021年第10期1054-1057,共4页
Oncology Progress
关键词
卵巢恶性肿瘤
静脉血栓栓塞症
危险因素
组织学分化程度
临床分期
ovarian malignant tumor
venous thromboembolism
risk factor
degree of histological differentiation
clinical stage
