摘要
CeO_(2)纳米粒子价格低廉、用途广泛,在工业领域已经发展成为一种成熟的工程化纳米材料。近年来,得益于独特的催化性能,纳米CeO_(2)被发现具有多种酶的活性,包括超氧化物歧化酶、过氧化氢酶、氧化酶、过氧化物酶、卤素过氧化物酶和磷酸酶等活性。简述了CeO_(2)纳米酶的多酶活性,并概括了相应模拟酶活性在生物分析、细菌感染、炎症、癌症和神经退行性疾病等领域的最新研究进展,对CeO_(2)纳米酶的改良及生物应用的拓展提出了展望。
Due to the low price and wide application,ceria nanoparticles have been developed into a mature engineering nano material in the industrial field.In recent years,derived from unique catalytic performance,nanoceria has been found to possess a variety of enzymatic activities,including superoxide dismutase,catalase,oxidase,peroxidase,haloperoxidases and phosphatase.This review briefly introduced the multi-enzyme activities of ceria nanozyme,and summarized the current progress of the corresponding enzymatic activity in the fields of biological analysis,bacterial infection,inflammation,cancer and neurodegenerative diseases.Finally,the challenges and the prospect of ceria nanozyme are also proposed.
作者
孙玉环
赵传奇
吴思
魏跃
曲晓刚
Sun Yuhuan;Zhao Chuanqi;Wu Si;Wei Yue;Qu Xiaogang(Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;School of Applied Chemistry and Engineering,University of Science and Technology,of China,Hefei 230026,China)
出处
《中国稀土学报》
CAS
CSCD
北大核心
2021年第3期436-446,共11页
Journal of the Chinese Society of Rare Earths
基金
国家重点研发计划项目(2019YFA0709202)
国家自然基金委项目(91856205,21820102009)资助。
