摘要
目的探讨颈动脉彩超联合血清脂蛋白相关磷脂酶A2(Lp-PLA2)在冠心病高危人群中的应用价值。方法选取2018年1月~2021年1月在我院就诊的冠心病高危人群300例,分析冠心病和非冠心病患者颈动脉中膜厚度、斑块及血清Lp-PLA2差异,采用受试者工作特征曲线(ROC)分析颈动脉中膜厚度、斑块及血清Lp-PLA2预测冠心病、多支病变的价值。结果经冠脉造影检查确诊冠心病患者73例,冠心病发生率为24.33%;冠心病患者颈动脉中膜厚度、颈动脉斑块比例、血清Lp-PLA2高于非冠心病患者(P<0.05);冠心病多支病变患者颈动脉中膜厚度、颈动脉斑块比例、血清Lp-PLA2分高于单支病变患者(P<0.05);颈动脉中膜厚度、斑块、Lp-PLA2联合预测冠心病的ROC曲线下面积为0.821(P<0.05),诊断敏感度和特异性分别为80.00%和78.50%;颈动脉中膜厚度、斑块、Lp-PLA2联合预测冠心病多支病变的ROC曲线下面积为0.894(P<0.05),诊断敏感度和特异性分别为92.00%和82.50%。结论颈动脉彩超联合血清Lp-PLA2在冠心病高危人群筛查中有较好的应用价值,在诊断冠心病及多支病变中价值较高。
Objective To investigate the application value of carotid artery color Doppler ultrasound combined with serum lipoprotein associated phospholipase A2(Lp-PLA2)in high-risk population of coronary heart disease.Methods A total of 300 patients with high risk of coronary heart disease in our hospital from January 2018 to January 2021 were selected.The differences of carotid artery media thickness,plaque and serum Lp-PLA2 between coronary heart disease and non coronary heart disease patients were analyzed.The receiver operating characteristic curve(ROC)was used to analyze the value of carotid artery intima-media thickness,plaque and serum Lp-PLA2 in predicting coronary heart disease and multivessel disease.Results There were 73 patients with coronary heart disease diagnosed by coronary angiography,and the incidence of coronary heart disease was 24.33%.The carotid media thickness,carotid plaque ratio and serum Lp-PLA2 in coronary heart disease patients were significantly higher than that in patients without coronary heart disease(P<0.05).In patients with multi vessel coronary artery disease,carotid artery intima-media thickness,carotid artery plaque ratio and serum Lp-PLA2 were significantly higher than that in patients with single vessel disease(P<0.05).The area under the ROC curve of carotid media thickness,plaque and Lp-PLA2 joint in predicting coronary heart disease was 0.821(P<0.05),the sensitivity and specificity were 80.00%and 78.50%respectively.The area under the ROC curve of carotid intima-media thickness,plaque and Lp-PLA2 joint in predicting multi vessel lesions of coronary heart disease was 0.894(P<0.05),the diagnostic sensitivity and specificity were 92.00%and 82.50%respectively.Conclusion Carotid artery color Doppler ultrasound combined with serum Lp-PLA2 has good application value in the screening of high-risk population of coronary heart disease.It has high value in the diagnosis of coronary heart disease and multi vessel disease.
作者
张成辉
张瑜
胡珊
ZHANG Chenghui;ZHANG Yu;HU Shan(Department of Ultrasound,the Dazu District People's Hospital,Chongqing 402360,China)
出处
《分子影像学杂志》
2021年第4期686-690,共5页
Journal of Molecular Imaging
关键词
颈动脉彩超
脂蛋白相关磷脂酶A2
冠心病
高危人群
诊断价值
color Doppler ultrasound of carotid artery
lipoprotein associated phospholipase A2
coronary heart disease
high risk group
diagnostic value
