摘要
目的探讨血小板计数(PLT)、红细胞分布宽度(RDW)、血小板体积(MPV)与急性肺栓塞(APE)病情分度的相关性。方法选择本院诊治的134例APE患者(APE组),根据危险分层标准分为低危、中危和高危组,另选择同期本院体检健康人102例作为对照组。收集两组性别、年龄等一般资料,检测PLT、RDW和MPV水平进行比较,并分析上述指标与APE患者病情分度相关性。结果APE组PLT水平低于对照组,RDW和MPV水平高于对照组(P<0.05);ROC曲线分析显示三者联合的曲线下面积(AUC)最大,诊断效能最高,联合诊断的敏感度为70.4%,特异度为91.8%(P<0.05);高危组PLT水平低于低危、中危组,RDW、MPV水平高于低危、中危组(P<0.05);PLT与病情分度呈负相关,RDW、MPV与病情分度呈正相关(P<0.05)。结论APE患者RDW、MPV水平异常升高,且与患者严重程度呈正相关;PLT水平异常降低,且与疾病严重程度呈负相关,三者联合可提高APE诊断效能,有利于评估预后。
Objective To analyze the correlation between hematology indexes such as platelet count(PLT),red blood cell distribution width(RDW)and mean platelet volume(MPV)and the severity of acute pulmonary embolism(APE).Methods A total of 134 APE patients(APE group)who were diagnosed and treated in our hospital were enrolled.According to the risk stratification criteria,they were divided into low-risk,moderate-risk and high-risk subgroups.Another 102 healthypeoplewho came to our hospital for physical examination during the same period were enrolled as control group.The general data such as gender and age in both groups were collected.The levels of PLT,RDW,and MPV were detected and compared between the APE group and the control group as well as among the APE subgroups.The correlation between the above indexes and APE severity were analyzed.Results PLT level in the APE group was significantly lower than that in the control group while RDW and MPV levels were significantly higher than those in the control group(P<0.05).ROC curves analysis showed that the area under the curve(AUC)of PLT combined with RDW and MPV was the largestand the diagnostic efficiency was the highest.The diagnostic sensitivity and specificity of their combination were 70.4%and 91.8%,respectively(P<0.05).PLT level in the high-risk subgroup was significantly lower than that in the low-risk and moderate-risk subgroups while RDW and MPV levels were significantly higher than those in the low-risk and moderate-risk groups(P<0.05).PLT was negatively correlated with disease severity while RDW and MPV were positively correlated with it(all P<0.05).Conclusion The levels of RDW and MPV in APE patients are abnormally increased,which are positively correlated with disease severity.PLT level is abnormally decreased,which is negatively correlated with disease severity.The combination of the three parameters can improve the efficiency of diagnosing APE,which alsobenefits prognosis.
作者
周宁希
刘士广
陈明菊
ZHOU Ning-xi;LIU Shi-guang;CHEN Ming-ju(Department of Medicine Laboratory,Xichang People's Hospital,Xichang 615000,China;Department of Respiratory and Critical Care Medicine,Xichang People's Hospital,Xichang 615000,China)
出处
《实用医院临床杂志》
2021年第4期144-147,共4页
Practical Journal of Clinical Medicine
关键词
血小板计数
红细胞分布宽度
血小板体积
急性肺栓塞
相关性
Platelet count
Red blood cell distribution width
Mean platelet volume
Acute pulmonary embolism
Correlation
