摘要
目的:评价生精汤治疗肾虚型少弱精症的临床疗效。方法:采用临床随机对照试验研究,纳入肾虚型少弱精症患者60例,随机分为治疗组及对照组,每组30例,治疗组给予生精汤+生活方式指导治疗,对照组给予生活方式指导治疗,观察治疗前后两组患者临床疗效、精子相关参数、临床症状自评量表SCL-90、性激素水平及抗精子抗体变化情况。结果:共纳入患者60例,在治疗过程中依从性良好,无脱落病例;两组患者在一般资料上比较无统计学差异(P>0.05),具有可比性;治疗组总有效率为96.7%(29/30),对照组总有效率为56.7%(17/30),治疗组明显优于对照组(P<0.05);治疗组患者的精液量、精子活动率、密度、a级精子、a+b级精子水平治疗后与治疗前比较均明显升高(P<0.05);治疗组治疗后患者的精子活动率、密度、a级精子、a+b级精子水平明显高于对照组治疗后(P<0.05)。治疗组治疗后SCL-90量表评分F3-F7的评分均较治疗前降低(P<0.05),对照组治疗后F3评分较治疗前降低(P<0.05)。治疗组治疗后患者的促黄体生成素(LH)、促卵泡刺激素(FSH)以及睾酮(T)的水平较治疗前均升高,差异有统计学意义(P<0.05),抗精子抗体水平治疗后较治疗前明显降低,差异有统计学意义(P<0.05);两组治疗后抗精子抗体水平比较,治疗组明显低于对照组(P<0.05);治疗组治疗后LH、T水平明显高于对照组治疗后,差异有统计学意义(P<0.05)。结论:生精汤有助于促进下丘脑-垂体-性腺轴的内分泌功能和调节促性腺激素的分泌,提高T浓度,恢复性腺轴的正常功能,调节性激素水平;降低抗精子抗体,减少精子聚集,显著提高精子活动力;应用生精汤治疗后能够改善患者人际关系、情绪焦虑等生理心理的症状,提高患者的生活质量,临床值得推广应用。
Objective:To evaluate the clinical efficacy of Shengjing Decoction in treating oligoasthenospermia of Kidney-deficiency pattern.Methods:60 patients with oligoasthenospermia of Kidney-deficiency pattern were randomly divided into the treatment group and the control group,with 30 cases in each group.The control group was given lifestyle guidance;on which basis,the treatment group was also treated with Shengjing Decoction.The clinical efficacy,the sperm related parameters,the scores of SCL-90,the sex hormone levels and the antibody changes of anti-sperm were observed before and after the treatment in the two groups.Results:A total of 60 patients were included in the study,the compliance was good and there were no cases falling off during the treatment.There were no statistical differences in the general status between the two groups before the treatment(P>0.05).The total effective rate of the treatment group was 96.7%(29/30),which was significantly higher than 56.7%(17/30)of the control group(P<0.05).The sperm volume,the sperm activity rate,the sperm density,as well as the levels of grade a sperm and grade a+b sperm were significantly higher after the treatment than those before the treatment in the treatment group(P<0.05).After the treatment,the sperm activity rate,the sperm density,the levels of grade a sperm and grade a+b sperm were significantly higher in the treatment group than those in the control group(P<0.05).The scores of SCL-90 scale and F3-F7 were lower after the treatment than those before the treatment in the treatment group(P<0.05).The score of F3 was lower after the treatment than that before the treatment in the control group(P<0.05).The levels of luteinizing hormone(LH),follicle stimulating hormone(FSH)and testosterone(T)were significantly higher(P<0.05),and the antibody levels of anti-sperm were significantly lower after the treatment than those before the treatment in the treatment group(P<0.05).The antibody levels of anti-sperm were significantly lower in the treatment group than those in the control group after the treatment(P<0.05).The levels of LH and T were significantly higher in the treatment group than those in the control group after the treatment(P<0.05).Conclusion:Shengjing Decoction can promote the secretion of hypothalamus-pituitary-gonad axis and regulate the secretion of gonadotropin,increase the level of T concentration and restore the normal function of gonad axis,as well as regulate the level of sex hormone;it can reduce the antibody of anti-sperm,decrease the sperm aggregation and significantly improve the sperm motility.Shengjing Decoction can improve the physiological and psychological symptoms of the patients,such as interpersonal relationship and emotional anxiety,and improve the quality of life of the patients.The therapy is worthy of clinical application.
作者
马明
张景欣
徐芳
安立文
MA Ming;ZHANG Jingxin;XU Fang;AN Liwen(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中医药学报》
CAS
2021年第7期84-88,共5页
Acta Chinese Medicine and Pharmacology
基金
国家中医临床研究基地业务建设第二批科研专项课题(JDZX2015055)
黑龙江省中医药科研项目(ZHY-2020-115)
黑龙江省省级名中医师承工作项目。
关键词
男性不育
少弱精症
精子参数
生精汤
肾虚型
Male sterility
Oligoasthenospermia
Sperm parameters
Shengjing Decoction
Kidney-deficiency pattern
