摘要
【目的】探讨Nrf2在子宫内膜样腺癌组织中的表达及其意义。【方法】收集2012年1月至2015年12月本院病理科5例正常子宫内膜、12例子宫内膜增生、11例子宫内膜非典型增生和26例子宫内膜样腺癌组织标本,采用免疫组化方法检测各组织中Nrf2的表达水平,分析其临床意义。【结果】Nrf2在子宫内膜样腺癌、子宫内膜增生、子宫内膜非典型增生和正常子宫内膜中阳性高表达率分别为88.5%(23/26)、66.7%(8/12)、63.6%(7/11)、40%(2/5);子宫内膜样腺癌组织中Nrf2高表达率高于其余各组,差异具有统计学意义(P<0.05)。Nrf2高表达率与子宫内膜样腺癌患者的年龄、分级、脉管内有无癌栓无关(P>0.05),而与分期、淋巴结是否转移、癌组织浸润肌层深度有关(P<0.05)。【结论】Nrf2在子宫内膜样腺癌组织中过表达,其在子宫内膜样腺癌的发生、发展及转移中有一定的促进作用。
【Objective】To investigate the expression and significance of Nrf2 in endometrioid adenocarcinoma.【Methods】From January 2012 to December 2015,5 cases of normal endometrium,12 cases of endometrial hyperplasia,11 cases of endometrial atypical hyperplasia and 26 cases of endometrioid adenocarcinoma were collected in the Department of pathology of our hospital.The expression level of Nrf2 in each tissue was detected by immunohistochemical method,and its clinical significance was analyzed.【Results】The high expression rate of Nrf2 in endometrioid adenocarcinoma,endometrial hyperplasia,atypical hyperplasia and normal endometrium was 88.5%(23/26),66.7%(8/12),63.6%(7/11)and 40%(2/5),respectively.The high expression rate of Nrf2 in endometrioid adenocarcinoma was significantly higher than that in normal endometrium,and the difference was statistically significant(χ^(2)=6.31,P<0.05);There was no significant difference in the high expression rate between the other groups(mean P>0.05).The high expression rate of Nrf2 was not related to the age,stage,grade,tumor thrombus in vessels and the depth of myometrial invasion(mean P>0.05),but related to lymph node metastasis(P<0.05).【Conclusion】Nrf2 is overexpressed in endometrioid adenocarcinoma,which may play a role in promoting the occurrence,development and metastasis of endometrioid adenocarcinoma.
作者
耿文静
吴又明
王金生
李纳
单立兵
GENG Wen-jing;WU You-min;WANG Jin-sheng(Department of Pathology,Xiaolan People’s Hospital,Guangdong Zhongshan 528415)
出处
《医学临床研究》
CAS
2021年第6期918-920,共3页
Journal of Clinical Research
