摘要
目的探讨人群尿碘水平与血清一氧化氮浓度的相关性,为高碘致自身免疫性甲状腺疾病的发病机理提供依据。方法随机抽取江苏省高水碘地区妇女尿样和血样,采用砷铈催化分光光度法测定尿中碘含量,Griess反应方法测定血清中NO含量。结果尿中碘含量与血清NO浓度呈正相关(r=0.2981,P<0.05)。与尿碘值介于100~300μg/L的人群相比,尿碘值>300μg/L的人群血清NO浓度明显升高(Z=-1.89,P<0.05)。结论人群尿碘水平与血清NO浓度呈正相关,提示NO可能与高碘地区人群自身免疫性甲状腺疾病的发生和发展相关。
Objective To investigate the correlation between urinary iodine levels and serum nitric oxide levels in the population.Method Urine samples and blood samples of women aged 20 to 60 in the high iodine areas of Jiangsu Province were randomly selected.The concentration of urinary iodine was estimated by Arsenic and cerium catalytic spectrophotometry and the concentration of serum nitric oxide was estimated by Griess reaction method.Result There was a positive correlation between urinary iodine levels and serum nitric oxide levels(r=0.2981,P<0.05).Compared with the population of 100~300μg/L urinary iodine,the concentration of serum nirtic oxide increased significantly in the population with the urinary iodine of more than 300μg/L(Z=-1.89,P<0.05).Conclusion There is a positive correlation between urinary iodine levels and serum nitric oxide levels in the population,indicating that nitric oxide may be associated with the occurrence and development of autoimmune thyroid disease of the population in the high iodine areas.
作者
谭雪
曹晓晓
马巍
徐菁
TAN Xue;CAO Xiao-xiao;MA Wei;XU Jing(Wanzhou District Centre for Disease Control and Prevention,Chongqing 404000,China;不详)
出处
《中国地方病防治》
CAS
2021年第3期212-214,共3页
Chinese Journal of Control of Endemic Diseases
