摘要
目的观察逍遥散治疗混合性焦虑抑郁障碍肝郁脾虚证的临床疗效。方法采用随机、对照的方法,将150例混合性焦虑抑郁患者障碍随机分为观察组和对照组,每组各75例。观察组患者服用逍遥散,对照组患者服用氟哌噻吨美利曲辛片治疗4周,随访1个月,并采用汉密顿抑郁(HAMD)量表、汉密顿焦虑(HAMA)量表和中医证候量表进行疗效评定。结果治疗4周后,观察组患者HAMD评定总有效率为86.3%、HAMA评定总有效率为79.4%,对照组HAMD评定总有效率为77.8%、HAMA评定总有效率为72.2%,差异均无统计学意义(均P>0.05),但观察组HAMD量表的焦虑/躯体化因子得分[(3.5±1.4)分]明显低于对照组[(4.6±1.3)分](P<0.01),睡眠障碍因子得分[(2.6±1.3)分]明显低于对照组[(3.3±1.4)分](P<0.01)。观察组治疗2周、4周时,中医证候改善明显,与对照组比较差异有统计学意义(P<0.01)。治疗结束后1个月,对照组HAMD、HAMA及其因子分均较治疗4周时升高,差异均有统计学意义(P<0.01);但是观察组HAMD、HAMA及其因子得分与治疗4周时比较,差异无统计学意义(P>0.05)。结论逍遥散和氟哌噻吨美利曲辛片对改善混合性焦虑抑郁的症状均有明显的效果,但逍遥散对患者焦虑、躯体化及睡眠障碍等方面的改善作用和远期效果优于氟哌噻吨美利曲辛片。
Objective To observe the clinical effect of Xiaoyao Powder in the treatment of mixed anxiety and depression with liver depression and spleen deficiency type. Methods A totally of 150 patients with mixed anxiety and depression were randomly divided into observation group and control group,with 75 cases in each group. The observation group was treated with Xiaoyao Powder,while the control group was treated with Flupentixol and Melitracen tablets for 4 weeks. The patients were followed up for 1 month. The Hamilton Depression(HAMD)scale,Hamilton anxiety(HAMA)scale and Traditional Chinese Medicine syndrome scale were evaluated. Results After 4 weeks of treatment,the total effective rates of HAMD and HAMA were 86. 3% and 79. 4% respectively in the observation group and 77. 8% and 72. 2% respectively in the control group.There was no significant difference between the two groups(P>0. 05),but the anxiety/somatization factor score of HAMD in the observation group[(3. 5±1. 4)scores]was significantly lower than that in the control group[(4. 6±1. 3)scores](P<0. 01),and the score of sleep disorder factor[(2. 6±1. 3)scores]was significantly lower than that of control group[(3. 3±1. 4)scores](P<0. 01). After 2 and 4 weeks of treatment,the Traditional Chinese Medicine Syndromes of the observation group were significantly improved,and there was a significant difference compared with the control group(P<0. 01). At 1-month follow-up,HAMD,HAMA and their factor scores in the control group were significantly higher than those at 4 weeks of treatment(P<0. 01). However,there was no significant difference in HAMD,HAMA and their factor scores between the two groups(P>0. 05).Conclusion Both Xiaoyao Powder and Flupentixol Melitracen tablets have obvious effect on improving the symptoms of mixed anxiety and depression,but the improvement and long-term effect of Xiaoyao Poweler on anxiety,somatization and sleep disorders are better than Flupentixol Melitracen tablets.
作者
郑琴
孔祥文
孙文军
强思思
于静远
李兰
沈茜
鲁姝
ZHENG Qin;KONG Xiang-wen;SUN Wen-jun;QIANG Si-si;YU Jing-yuan;LI Lan;SHEN Qian;LU Shu(Department of Encephalopathy,Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China;Department of Pharmacy,Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China)
出处
《临床药物治疗杂志》
2021年第7期60-64,共5页
Clinical Medication Journal
基金
北京市科技计划课题首都特色项目(Z171100001017227)
2019年全国中药特色技术传承人才培训项目(T20194828003)。
关键词
逍遥散
混合性焦虑抑郁
汉密顿抑郁量表
汉密顿焦虑量表
中医证候量表
Xiaoyao Powder
mixed anxiety and depression
Hamilton pepression scale
Hamilton anxiety scale
Tradi-tional Chinese Medicine syndrome scale
