摘要
目的研究中晚期非小细胞肺癌(NSCLC)预后情况并分析其与患者血清D-二聚体(D-D)、红细胞分布宽度(RDW)、β_(2)微球蛋白(β_(2)-MG)水平的关系。方法回顾性分析2016年6月至2019年1月我院75例中晚期NSCLC患者临床资料,根据预后分为死亡组39例和存活组36例,比较两组血清D-D、RDW、β_(2)-MG水平差异,分析其对中晚期NSCLC患者预后的预测价值。结果75例中晚期NSCLC患者随访期间死亡39例(52.00%),中位总体生存(OS)时间、无进展生存(DFS)时间分别为18.0(95%CI:14.9~21.1)、12.0(95%CI:10.1~13.9)个月;化疗前死亡组血清D-D、RDW、β_(2)-MG水平明显高于存活组(P<0.05),化疗后两组比较无明显差异(P>0.05);D-D、RDW、β_(2)-MG与OS时间和DFS时间呈明显负相关性(P<0.05),且单纯化疗者D-D、RDW、β_(2)-MG与OS时间和DFS时间均呈明显负相关性(P<0.05);D-D、RDW和β_(2)-MG为影响晚期NSCLC患者预后的独立因子(P<0.05);预测中晚期NSCLC患者死亡的AUC分别为0.638、0.709、0.865(P<0.05)。结论中晚期NSCLC患者预后较差且与血清D-D、RDW、β_(2)-MG水平紧密相关,检测D-D、RDW、β_(2)-MG可为评估患者预后提供参考依据。
Objective To study the prognosis of advanced non-small cell lung cancer(NSCLC)and analyze its relationship with the levels of serum D-dimer(D-D),red blood cell distribution width(RDW)andβ_(2) microglobulin(β_(2)-MG).Methods From June 2016 to January 2019,the clinical data of 75 patients with advanced NSCLC in our hospital were retrospectively analyzed.The patients were divided into the death group(39 cases)and the survival group(36 cases)according to the prognosis.The levels of serum D-D,RDW and β_(2)-MG were compared between the two groups,and their predictive value on prognosis of patients with advanced NSCLC was analyzed.Results Among the 75 patients with advanced NSCLC,39 cases(52.00%)died during follow-up,and the median overall survival(OS)time and disease-free survival(DFS)time were 18.0(95%CI:14.9~21.1)months and 12.0(95%CI:10.1~13.9)months.The levels of serum D-D,RDW and β_(2)-MG in the death group before chemotherapy were higher than those in the survival group(P<0.05),and the difference between the two groups was not statistically significant after chemotherapy(P>0.05).The levels of D-D,RDW and β_(2)-MG were significantly negatively correlated with OS and DFS(P<0.05),and D-D,RDW and β_(2)-MG of patients with chemotherapy alone were significantly negatively correlated with OS and DFS(P<0.05).D-D,RDW andβ_(2)-MG were independent factors affecting the prognosis of patients with advanced NSCLC(P<0.05),and the AUC values of D-D,RDW and β_(2)-MG in predicting death in patients with advanced NSCLC were 0.638,0.709 and 0.865(P<0.05).Conclusion The prognosis of patients with advanced NSCLC is poor and is closely related to the levels of serum D-D,RDW and β_(2)-MG.The detection of D-D,RDW and β_(2)-MG can provide a reference for evaluating the prognosis of patients.
作者
胡加海
陈荃
HU Jia-hai;CHEN Quan(Department of Medical Oncology,the First People's Hospital of Chuzhou,Chuzhou,Anhui 239000,China;Department of Internal Medicine,the First People's Hospital of Chuzhou,Chuzhou,Anhui 239000,China)
出处
《临床肺科杂志》
2021年第8期1221-1226,共6页
Journal of Clinical Pulmonary Medicine
关键词
非小细胞肺癌
中晚期
预后
D-二聚体
红细胞分布宽度
Β2微球蛋白
non-small cell lung cancer
advanced stage
prognosis
D-Dimer
red blood cell distribution width
β_(2)microglobulin
