The expresion of BDNF and GDNF in the trigeminal root entry zone and trigeminal ganglion neurons in trigeminal neuralgia animal model

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摘要 Microvascular compression on the trigeminal root entry zone(TREZ)is the main aetiology of trigeminal neuralgia(TN)patients.To investigate brain-derived neurotrophie factor(BDNF)and glial cell line derived neurotrophic factor(GDNF)in the trigeminal ganglion(TG)and TREZ,immunofluorescence staining and Western blot were used in a rat TN model.Both BDNF and GDNF were observed in the TG neurons and TREZ.The BDNF dimer in the TG increased in the TN group while the GDNF decreased after compression injury.The ratio of BDNF dimer/pro-BDNF in the TREZ of the TN group was higher than that in the sham group,but the GDNF in the TREZ was.

作者 Luo Daoshu Luo Lili Lin Ren

机构地区 Department of Human Anatomy

出处《解剖学杂志》 CAS 2021年第S01期120-120,共1页 Chinese Journal of Anatomy

关键词 TRIGEMINAL NEURALGIA GDNF

分类号 R74 [医药卫生—神经病学与精神病学]

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解剖学杂志

2021年第S01期

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The expresion of BDNF and GDNF in the trigeminal root entry zone and trigeminal ganglion neurons in trigeminal neuralgia animal model

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