摘要
人羊膜上皮细胞和人羊膜间充质干细胞存在于人羊膜组织中,统称为人羊膜细胞。人羊膜细胞可塑性强,具有多向分化的潜能;并且免疫原性低,移植不会发生免疫排斥反应,成为近年来研究的热点。人羊膜上皮细胞和人羊膜间充质干细胞的生物学特性使其符合干细胞药物产品的标准,将其应用于诸多疾病的治疗,如心肌梗死、脑梗死和肾损伤等,均已取得良好的疗效,此外还为许多疑难杂症提供了治疗方向。本文将从羊膜细胞的生物学特性、分离方法、表面标记物、分化潜能和对相关疾病的研究进展等方面进行综述。
Human amniotic epithelial cells and human amniotic mesenchymal stem cells exist in human amniotic tissue,which are called human amniotic cells.Human amniotic cells have strong plasticity and multi-directional differentiation potential.And cells are always with low immunogenicity that immune rejection will not occur often after transplantation.These characteristics make the cells become a research hotspot in recent years.At the same time,these characteristics also enable them to conform to the standards of stem cell drug products,which used in the treatment for many diseases,such as myocardial infarction,cerebral infarction,kidney injury and so on,the results were showed that it achieved good results.In addition,it also provides the treatment direction for many difficulty and complicated diseases.This article will review the biological characteristics,separation methods,surface markers,differentiation potential and the research progress of related diseases of human amniotic cells.
作者
薛玲玲
陈锦阳
庄盼
刘军权
Xue Lingling;Chen Jinyang;Zhuang Pan;Liu Junquan(Zhejiang Weiwei Biomedical Science and Technology Co.,Ltd,Hangzhou 310053,China;Hangzhou Golden Domain Medical Laboratory Co.,Ltd,Hangzhou 310053,China)
出处
《中华细胞与干细胞杂志（电子版）》
2021年第3期184-188,共5页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
关键词
人羊膜上皮细胞
人羊膜间充质干细胞
生物学特性
分化潜能
Human amniotic epithelial cells
Human amniotic mesenchymal stem cells
Biological characteristics
Differentiation potential
