摘要
目的:探讨川崎病患儿心率变异性(HRV)与PCT的相关性及其预测冠状动脉损伤的价值。方法:回顾性选取2017年1月至2019年6月在我院确诊的86例川崎病患儿作为研究对象,其中男性患儿46例,女性患儿40例,年龄1~5岁,平均年龄为2.53±1.14岁。患儿均于治疗前行超声心动图检查,根据是否出现冠状动脉损害可分为A组(冠状动脉损害组42例)和B组(非冠状动脉损害组44例),同时选择50例同期体检健康儿童作为对照组。分别对各组儿童行HRV指标(时域指标、频域指标)检测,并采用免疫荧光层析法检测各组儿童血清PCT水平。观察并比较三组儿童HRV时域指标及频域指标,并将各组患儿PCT水平进行对比。结果:川崎病患儿与对照组正常儿童比较,HRV时域指标及频域指标均存在统计学差异(P<0.05),同时A组患儿HRV各项指标明显低于B组,差异具有统计学意义(P<0.05)。A、B两组患儿血清PCT水平均明显高于对照组,且A组患儿血清PCT水平(2.85±1.28ng/mL)较B组(1.26±0.93ng/mL)显著升高(P<0.05)。结论:川崎病患儿心率变异性(HRV)与血清PCT水平存在较好的相关性,同时上述两项指标均可较准确地预测患儿是否出现冠状动脉损伤,具有较好的诊断价值,可适用于临床早期辅助诊断川崎病及川崎病合并冠状动脉损伤,从而为患儿的及时治疗提供依据,因此值得临床推广。
Objective:To explore the correlation between heart rate variability(HRV)and PCT in children with Kawasaki disease and its value in predicting coronary artery injury.Methods:86 cases of children with Kawasaki disease diagnosed in our hospital from January 2017 to June 2019 were retrospectively selected,including 46 male patients and 40 female patients,aged 1 to 5 years,average age 2.53±1.14 years old.All children underwent echocardiography before treatment.According to whether coronary artery damage occurred,they were divided into group A(coronary artery damage group,42 cases)and group B(non-coronary artery damage group,44 cases).Healthy children served as a control group.HRV indicators(time domain indicators,frequency domain indicators)were tested for children in each group,and the serum PCT levels of children in each group were detected by immunofluorescence chromatography.The three groups of children's HRV time domain indicators and frequency domain indicators were observed and compared,and the PCT levels of children in each group were compared.Results:The results showed that children with Kawasaki disease compared with normal children in the control group had statistically significant differences in HRV time-domain and frequency-domain indicators(P<0.05),and children in group A had significantly lower HRV indicators than group B.The difference was statistically significant(P<0.05).The serum PCT levels of children in groups A and B were significantly higher than those in the control group,and the serum PCT levels(2.85±1.28 ng/ml)in group A were significantly higher than those in group B(1.26±0.93 ng/ml)(P<0.05).Conclusion:There is a good correlation between heart rate variability(HRV)and serum PCT levels in children with Kawasaki disease.At the same time,the above two indicators can more accurately predict whether children will have coronary artery injury.It has good diagnostic value and is suitable for the early clinical diagnosis of Kawasaki disease and Kawasaki disease combined with coronary artery injury,so as to provide a basis for the timely treatment of children.It is worthy of clinical promotion.
作者
罗洁
李晓忠
闵月
许秋艳
董永超
陆敏
LUO Jie(Suzhou Science and Technology Town Hospital,Nanjing Medical University,Jiangsu Suzhou 215153,China)
出处
《河北医学》
CAS
2021年第7期1215-1219,共5页
Hebei Medicine
基金
2018年苏州市科技计划项目,(编号:SZS201808)。
关键词
川崎病
心率变异
PCT
冠状动脉
患儿
Kawasaki disease
Heart rate variability
PCT
Coronary artery
Child patients
