摘要
目的了解中国地区新型冠状病毒感染者的密切接触人群严重急性呼吸综合征冠状病毒(SARS-CoV-2)核酸阳性率的现状。方法检索PubMed,EMbase,中国期刊全文数据总库(CNKI)、万方科技期刊全文数据库、维普中文科技期刊全文数据库(VIP)中有关中国地区新型冠状病毒感染者的密切接触人群SARS-CoV-2核酸检测相关文献,检索时间为2019年12月~2020年12月24日。参照修改后的美国卫生保健研究与质量机构(AHRQ)声明评价文献质量。采用StataSE15.0软件进行meta分析,利用Freeman-Tukey双反正弦转换法计算合并的阳性率,根据性别、年龄、感染人员关系、感染方式及接触频率进行亚组分析,并进行敏感性分析及Egger法检验发表偏倚。结果共纳入11篇文献,总样本量为24906例,新型冠状病毒感染者的密切接触人群SARS-CoV-2核酸阳性率为5.42%(95%CI:3.57%~7.64%),亚组分析显示,男性阳性率为4.35%,女性阳性率为6.36%;0~9岁组阳性率为5.88%,10~59岁组为4.76%,≥60岁组为8.73%;家庭成员组阳性率为13.42%,其它为2.09%;共同生活人员阳性率为11.44%,聚餐为9.90%,其它感染方式组为1.95%;偶尔接触者、一般接触者、经常接触者阳性率分别为1.32%,6.12%和9.60%,各亚组间差异均有统计学意义(χ^(2)=37.89~809.90,均P<0.05)。敏感度分析提示结果稳定,Egger法检验发表偏倚为差异无统计学意义(t=0.93,P=0.376)。结论中国地区新型冠状病毒感染者的密切接触人群SARS-CoV-2核酸具有一定的阳性率。
Objective To investigate the SARS-CoV-2 nucleic acid positive rate in close contacts of the patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.Methods Relevant literatures about SARS-CoV-2 nucleic acid testing in close contacts of patients with Corona Virus Disease 2019 in Chinese population were retrieved from PubMed,Embase,CNKI,Wanfang and VIP database from December 2019 to December 24,2020.The quality of article was assessed through the revised AHRQ statement.Statase15.0 software was used for meta-analysis,and Freeman-Tukey double arsinusoidal conversion method was used to calculate the positive rate of the combination.Subgroup analysis was performed according to gender,age,relationship of infected persons,infection mode and contact frequency,sensitivity analysis and publication bias test were also conducted.Results A total of 24906 individuals were included in the Meta-analysis of the 11 literatures.The SARS-CoV-2 nucleic acid positive rate of close contacts of people suffering from SARS-CoV-2 was 5.42%(95%CI:3.57%~7.64%),subgroup analysis showed that the positive rate of male was 4.35% and that of female was 6.36%.The positive rate was 5.88%in the group of 0~9 years old,4.76% in the group of 10~59 years old and 8.73% in the group of≥60 years old.The positive rate was 13.42% in family members group and 2.09% in others group.The positive rate of people living together was 11.44%,that of people having dinner together was 9.90%,and that of people with other infection modes was 1.95%;The positive rate of occasional contacts,general contacts and regular contacts were 1.32%,6.12%and 9.60%,respectively.There was significant difference among subgroups(χ^(2)=37.89~809.90,all P<0.05).Sensitivity analysis showed that the results were stable,and the publication bias of egger test was not statistically significant(t=0.93,P=0.376).Conclusion There was a certain positive rate of SARS-CoV-2 nucleic acid in close contacts of the patients attacked by SARS-CoV-2 in China.
作者
许涛
杨磊
高玉芳
张建平
XU Tao;YANG Lei;GAO Yu-fang;ZHANG Jian-ping(Department of Clinical Laboratory,Xianyang Central Hospital,Shaanxi Xianyang 712000,China;Department of Reproductive Medicine,Xianyang Central Hospital,Shaanxi Xianyang 712000,China)
出处
《现代检验医学杂志》
CAS
2021年第4期122-128,共7页
Journal of Modern Laboratory Medicine
关键词
新型冠状病毒病
密切接触者
严重急性呼吸综合征冠状病毒2
核酸
阳性率
corona virus disease 2019
close contacts
severe acute respiratory syndrome coronavirus 2
nucleic acid
positive rate
