摘要
目的:探讨不同中医辨证分型乳腺癌患者微血管生长及预后情况。方法:选取90例乳腺癌患者,依据中医证型不同分为肝郁气滞证组(42例)、肝肾阴虚证组(30例)、血瘀证组(18例)。比较3组血管生长因子(VEGF)、碱性成纤维生长因子(b FGF)、人类表皮生长因子受体2(HER-2)阳性表达率,微血管密度(MVD),TNM分期及病理组织学分级。结果:血瘀证组VEGF、b FGF、HER-2阳性表达率均高于肝郁气滞证组和肝肾阴虚证组(P<0.05),肝肾阴虚证组VEGF、b FGF、HER-2阳性表达率均高于肝郁气滞证组(P<0.05)。血瘀证组MVD高于肝郁气滞证组和肝肾阴虚证组,肝肾阴虚证组MVD高于肝郁气滞证组(P<0.05)。肝郁气滞证组和肝肾阴虚证组TNM分期以Ⅰ期、Ⅱ期为主;血瘀证组则以Ⅱ期、Ⅲ期为主。肝郁气滞证组病理组织学分级以Ⅰ级为主,肝肾阴虚证组以Ⅱ级为主,血瘀证组则以Ⅲ级为主。结论:不同中医证型乳腺癌患者微血管生成作用不尽相同,且预后存在差异,其中血瘀证乳腺癌患者微血管生成作用较强,预后较差,而肝郁气滞证乳腺癌患者微血管生成作用较弱,预后较好。
Objective:To discuss the microvessel growth and prognosis of patients with breast cancer of different Chinese medicine syndrome types. Methods:A total of 90 cases of patients with breast cancer were selected and divided into three groups according to different Chinese medicine syndromes,namely the liver depression and qi stagnation group(42 cases),the liver-kidney yin deficiency group(30 cases),and the blood stasis group(18 cases). The positive expression rates of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),and human epidermal growth factor receptor-2(HER-2),the level of microvascular density(MVD),TNM staging,as well as histopathological grading were compared among the three groups.Results:The positive expression rates of VEGF and b FGF and HER-2 in the blood stasis group were higher than those in the liver depression and qi stagnation group and the liver-kidney yin deficiency group(P<0.05),the positive expression rates of VEGF and b FGF and HER-2 in the liver-kidney yin deficiency group were higher than those in the liver depression and qi stagnation group(P<0.05). The MVD in the blood stasis group was higher than those in the liver depression and qi stagnation group and the liver-kidney yin deficiency group,and the level in the liver-kidney yin deficiency group was higher than that in the liver depression and qi stagnation group(P<0.05). The TNM staging of the liver depression and qi stagnation group and the liver-kidney yin deficiency group were mainly stageⅠ and Ⅱ;the blood stasis group was mainly in stage Ⅱ and Ⅲ. As for the histopathological grading,the liver depression and qi stagnation group was mainly in gradeⅠ,the liver-kidney yin deficiency group was mainly grade Ⅱ,and the blood stasis group was mainly grade Ⅲ.Conclusion:The microvessel growth and prognosis differ among patients with breast cancer of different Chinese medicine syndrome types. Among them,patients with blood stasis syndrome have better microvessel growth and a worse prognosis,and patients with the liver depression and qi stagnation syndrome have weaker microvessel growth and a better prognosis.
作者
张耀飞
沈艳华
郑颖
毛银花
徐甜甜
ZHANG Yaofei;SHEN Yanhua;ZHENG Ying;MAO Yinhua;XU Tiantian
出处
《新中医》
CAS
2021年第13期127-130,共4页
New Chinese Medicine
关键词
乳腺癌
中医证型
肝郁气滞证
肝肾阴虚证
血瘀证
微血管生长
预后
Breast cancer
Chinese medicine syndrome type
Liver depression and qi stagnation syndrome
Liver-kidney yin deficiency syndrome
Blood stasis syndrome
Microvessel growth
Prognosis
