摘要
在过去的30年中,随着甲型肝炎、乙型肝炎和戊型肝炎的疫苗普及,全球在控制病毒性肝炎的新发感染率和发病率上取得了巨大效果。与此同时,随着针对丙型肝炎的新型抗病毒药物的成功研发,也为消除丙型肝炎的公共卫生威胁带来希望。然而,由于病毒性肝炎的早期诊断率不高、疫苗和抗病毒药物的获得性在国家或地区间不均衡以及对病毒性肝炎危害性的认识不足等原因,病毒性肝炎的疾病负担依然较重,仍是一项全球性的公共卫生问题。因此,消除病毒性肝炎的公共卫生危害需要完善现有的应对策略,强化疫苗免疫、扩大筛查力度、普及抗病毒治疗等综合性措施。本文就全球及中国病毒性肝炎的流行概况、防治现状、WHO消除病毒性肝炎公共卫生危害的目标及所采取的行动计划作一探讨。
In the past three decades,with the implementation of vaccinating against hepatitis A,hepatitis B and hepatitis E,it has achieved remarkable achievements in controlling incidence and prevalence of viral hepatitis.At the same time,the successful development of direct-acting antiviral agents(DAA)for hepatitis C also brings hope for eliminating the public health threat of hepatitis C.However,due to the low rate of early diagnosis of viral hepatitis,the uneven availability of vaccines and antiviral drugs among countries or regions,and the lack of awareness of the harmfulness of viral hepatitis,the disease burden of viral hepatitis is still heavy.It remains a severe public health problem in global.Therefore,to eliminate the public health threat of viral hepatitis,it is necessary to improve the existing coping strategies,strengthen vaccine immunization,expand screening,and popularize antiviral treatment and other comprehensive measures.This article discusses the epidemic situation of viral hepatitis in China and the world,the current situation of prevention and treatment,the goal of WHO to eliminate the public health threat of viral hepatitis,and the action plan adopted.
作者
杨仕贵
YANG Shi-gui(The First Affiliated Hospital,College of Medicine,Zhejiang University,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University,National Clinical Research Center for Infectious Diseases Zhejiang University,Hangzhou 310003,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2021年第7期749-752,共4页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81672005,U1611264)
国家科技重大专项(2018ZX10715-014-002,2014ZX10004008)
科技部中青年科技创新领军人才(2017RA2120)。
关键词
病毒性肝炎
疾病负担
预防控制
Viral hepatitis
Disease burden
Prevention and control
