摘要
目的评估细胞学、高危型人乳头瘤病毒(high risk human papillomavirus,HR-HPV)与阴道镜结果的不同组合发生宫颈上皮内瘤变≥2级(cervical intraepithelial neoplasia grade 2 or worse,CIN2+)的风险。方法选取2018年1月―2018年12月深圳市妇幼保健院阴道镜门诊数据库中822例患者的临床数据资料,基于细胞学、HR-HPV和阴道镜结果,分析患者发生CIN2+的风险差异。结果若发现其中两种检查结果高度异常(细胞学高度上皮内瘤变及以上(high-grade squamous intraepithelial lesion or worse,HSIL+)、HPV16/18+、阴道镜高级别病变),则发生CIN2+的风险高于60%;若发现三种高度异常,则发生CIN2+的风险为97.1%。结论当发现细胞学、HR-HPV和阴道镜结果中至少2种异常情况,未来进展为CIN2+的风险较高,应予以重视,减少不必要的误诊和漏诊。
Objective To evaluate pooled risk of cervical intraepithelial neoplasia grade 2 or worse(CIN2+)based on the various combinations of cytology,HR-HPV(high risk human papillomavirus),and colposcopy impression.Methods 822 cases were selected from the colposcopy outpatient database of Shenzhen Maternity and Child Healthcare Hospital from January to December 2018.We assessed the risk of CIN2+based on the combinations of three test results(cytology,HR-HPV,and colposcopy).Results If two of the test results show highly abnormality(HSIL+,HPV16/18+and high-grade colposcopic impression),the risks for CIN2+would be over 60%.If three highly abnormal test results are found,the risk for CIN2+is 97.1%.Conclusions When at least two abnormal results in cytology HR-HPV and colposcopy are found,the CIN2+risk was quite high,and attention should be paid to reduce unnecessary misdiagnosis and missed diagnosis.
作者
张一方
薛鹏
唐朝
李晴
江宇
乔友林
ZHANG Yi-fang;XUE Peng;TANG Chao;LI Qing;JIANG Yu;QIAO You-lin(School of Population Medicine and Public Health,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Diagnosis and Treatment for Cervical Lesions Center,Shenzhen Maternity and Child Healthcare Hospital,Affiliated Hospital of the South Medical University,Shenzhen 518048,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2021年第7期812-816,842,共6页
Chinese Journal of Disease Control & Prevention
基金
中国医学科学院医学与健康科技创新工程项目(CIFMS2017-I2M-B&R-03)。
