摘要
目的探讨河南省艾滋病高发地区通过性传播途径感染艾滋病的患者高脂血症患病率及影响因素。方法以河南省"艾滋病常规治疗数据库"为数据信息来源,抽取2018年登记在册的性传播艾滋病患者,收集人口学信息、HAART治疗信息及实验室检查结果等。使用SPSS19.0软件,采用单因素、多因素分析探究性传播艾滋病患者高脂血症患病率及影响因素。结果本研究共纳入1020例性传播艾滋病患者,男616例(60.39%),女404例(39.61%)。248例合并高脂血症(24.31%),参与中药治疗项目、CD4^(+)T细胞计数>500个/mm^(3)、HAART治疗时间>10年、服用含克力芝治疗方案的患者患病率较高,分别为39.47%、37.27%、36.08%、34.24%。单因素分析提示,HIV阳性确诊时间、含克力芝治疗方案、HAART治疗时间、参与中药治疗项目以及CD4^(+)T细胞计数是性传播艾滋病患者高脂血症影响因素,差异有统计学意义(P<0.05);多因素分析提示,CD4^(+)T细胞计数>500个/mm^(3)(OR=3.673,95%CI:2.493~5.412)、服用含克力芝治疗方案(OR=1.688,95%CI:1.145~2.489)、HAART治疗>5年(OR=2.853,95%CI:1.378~5.906)/(OR=4.241,95%CI:1.663~10.817)、合并血糖升高(OR=1.534,95%CI:1.007~2.337)均是高脂血症独立危险因素,差异有统计学意义(P<0.05)。结论河南某地区性传播艾滋病患者高脂血症患病率约24.31%,总体处于较低水平。CD4^(+)T细胞计数>500个/mm^(3)、服用含克力芝治疗方案、HAART治疗时间>5年、合并血糖升高是性传播艾滋病患者高脂血症患病率的独立危险因素,应尽早给予患者饮食指导,动态监测血脂水平,必要时启动药物降血脂干预治疗。
Objective To explore the prevalence and its influence factors of hyperlipidemia in sexually transmitted infections of AIDS patients in Henan province.Methods The demographic information,HAART information and laboratory tests of hyperlipidemia were extracted from AIDS patients who were registered in"Database of routine AIDS Treatment"in 2018.The results were analyzed using SPSS19.0 software,univariate and multivariate.Results A total of 1020 patients with sexually transmitted AIDS were enrolled in this study,including 616(60.39%)males and 404(39.61%)females.There were 248 patients with hyperlipidemia(24.31%),who participated in Chinese Medicine treatment program,CD4^(+)T cell count was more than 500 cells/mm^(3),HAART treatment duration was more than 10 years,and taking the aluvia-based antiretroviral therapy had a higher prevalence rate(39.47%,37.27%,36.08%,34.24%,respectively).Univariate analysis showed that HIV positive diagnosis time,aluvia-based antiretroviral therapy,HAART treatment time,participating in Chinese Medicine treatment project and CD4^(+)T cell count were the influencing factors of hyperlipidemia,and the difference was statistically significant(P<0.05).Multivariate analysis showed that more than 500 cells/mm^(3) of CD4^(+)T cell count(OR=3.673,95%CI:2.493~5.412),aluvia-based antiretroviral therapy(OR=1.688,95%CI:1.145~2.489),5~10 years of HAART treatment(OR=2.853,95%CI:1.378~5.906),more than 10 years of HAART treatments(OR=4.241,95%CI:1.663~10.817),and elevated blood glucose(OR=1.534,95%CI:1.007~2.337)were independent risk factors of hyperlipidemia,and the difference was statistically significant(P<0.05).Conclusion The prevalence of hyperlipidemia is lower in sexually transmitted AIDS patients in a certain area of Henan Province.The duration of HAART for more than 5 years,CD4^(+)T cell count greater than 500 cells/mm^(3),using aluvia-based antiretroviral therapy and elevated blood glucose were independent risk factors for the prevalence of hyperlipidemia.Therefore,it is necessary to give patients diet guidance,dynamic monitoring of blood lipid level and even start the intervention therapy of lowering blood lipid with drugs as soon as possible.
作者
翟优
赵英强
刘亚楠
张积思
郭会军
ZHAI You;ZHAO Yingqiang;LIU Ya'nan;ZHANG Jisi;GUO Huijun(Henan University of Chinese Medicine,Zhengzhou 450000,China;The Second Affiliated Hospital of Tianjin University of Chinese Medicine,Tianjin 300000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2021年第8期897-903,共7页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金项目(81803953,81873187)
国家科技重大专项(2017ZX10205502002,2017ZX10205502003)。
关键词
艾滋病
性传播
高脂血症
患病率
AIDS
Sexual transmission
Hyperlipidemia
Prevalence rate
