摘要
高血压是脑小血管病(CSVD)最重要的危险因素之一,血压的调控在CSVD的发生、进展和预后中起着重要作用。血压变异性(BPV)反映的是血压在一定时间内波动的程度,异常的血压波动与高血压所致的靶器官损害具有紧密关联。因此,BPV也与CSVD的发生发展密切相关,是独立于平均血压之外的CSVD的危险因素。不同类型的BPV指标对CSVD的影响存在差异,目前潜在的作用机制尚不完全清楚,有待进一步研究深入探索相关机制,以期通过降低BPV来预防CSVD的发生,达到早期防治的目的。
Hypertension is one of the most important risk factors of cerebral small vessel disease(CSVD).The regulation of blood pressure plays an important role in the occurrence,progress and prognosis of CSVD.Blood pressure variability(BPV)reflects the degree to which blood pressure fluctuates over a certain period of time.Abnormal blood pressure fluctuations are closely related to target organ damage caused by hypertension.Therefore,BPV is also closely related to the occurrence and development of CSVD and is a risk factor for CSVD independent of mean blood pressure.Different types of BPV indexes have different effects on CSVD,and the potential mechanism is not completely clear at present,so further research is needed to explore the relevant mechanisms,so as to prevent the occurrence of CSVD and achieve the goal of early prevention and treatment by reducing BPV.
作者
张艺
鲍娟
谈跃
ZHANG Yi;BAO Juan;TAN Yue(Department of Cerebrovascular Disease,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
出处
《医学综述》
CAS
2021年第14期2819-2824,共6页
Medical Recapitulate
基金
昆明医科大学研究生创新基金(2020S190)。
关键词
脑小血管病
高血压
血压变异性
危险因素
Cerebral small vessel disease
Hypertension
Blood pressure variability
Risk factor
