摘要
急性髓细胞性白血病(AML)是获得性造血祖细胞变异而引起的克隆性疾病,病死率高,中医药经过长期的实践形成了治疗急性髓系白血病的中医理论,作用机制复杂。随着实验及临床研究水平的提高,有关中药作用于血液肿瘤细胞的机制研究深入分子层次。从诱导凋亡、调控周期、诱导分化、抑制转移与耐药性5个方面总结中药单体及复方作用于HL-60细胞的作用机制。为中医药抗白血病的实验研究奠定一定的理论基础。
Acute myeloid leukemia(AML)is a clonal disease caused by the variation of acquired hematopoietic progenitor cells,with a high mortality.After a long period of practice,traditional Chinese medicine has formed its theory for the treatment of the disease,and its mechanism of action is rather complex.With the improvement of the experimental and clinical research,the research on the mechanism of traditional Chinese medicine for the blood tumor cells has gone deep into the molecular level.This paper summarizes the action mechanism of TCM monomers and compounds for the HL-60 cells from five aspects:inducing the HL-60 cells apoptosis,regulating the HL-60 cells cycle,inducing the HL-60 cells differentiation,inhibiting the HL-60 cells metastasis and reversing the drug resistance in the HL-60 cells,anticipating to lay a theoretical foundation for the experimental study of traditional Chinese medicine against leukemia.
作者
张晓丹
周永明
王巍
ZHANG Xiaodan;ZHOU Yongming;WANG Wei(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《长春中医药大学学报》
2021年第4期909-913,共5页
Journal of Changchun University of Chinese Medicine
基金
国家自然科学基金项目(81373626)
上海市进一步加快中医药事业发展三年行动计划(ZY3-CCCX-3-2009)
上海市名老中医学术经验研究工作室(SHGZS-2017019)
上海中医药大学名老中医药专家学术经验研究工作室建设项目(SZYMZYGZS4018)。
关键词
HL-60细胞
急性髓系白血病
中药
研究进展
HL-60 cells
acute myeloid leukemia
traditional Chinese medicine(TCM)
research progress
