摘要
目的:探讨温胆汤对奥氮平所致代谢综合征患者糖脂代谢及肠道菌群的影响。方法:选择服用奥氮平合并代谢综合征、属于痰湿内阻型的患者120例随机分成两组。西药组在生活方式干预基础上联合二甲双胍治疗,中药组予温胆汤治疗。观察两组患者糖脂代谢的变化情况。采用荧光定量PCR检测正常对照组及中药组、西药组治疗前、治疗3个月后肠道菌群的拷贝数。结果:治疗3个月后两组的三酰甘油、胆固醇、高密度脂蛋白胆固醇、空腹血糖均有好转(P<0.01);中药组在降低三酰甘油、胆固醇方面的疗效优于对照组(P<0.01);中药组高密度脂蛋白胆固醇升高较西药组明显(P<0.05)。两组治疗前双歧杆菌属、乳酸杆菌属低于正常对照组,肠杆菌属高于正常对照组,P<0.05。治疗3个月后,两组双歧杆菌属、乳酸杆菌均升高,肠杆菌属下降,P<0.05;中药组乳酸杆菌、双歧杆菌属的升高较西药组更明显,P<0.05。结论:与二甲双胍相比,温胆汤在改善脂代谢紊乱方面有较好优势,可能通过调节肠道菌群发挥效果。
Objectives:To investigate the effects of the Wendan decoction on glucose and lipid metabolism and intestinal flora in patients with metabolic syndrome caused by Olanzapine.Methods:120 patients were randomly divided into two groups.The western medicine group was treated with metformin and lifestyle intervention,while the TCM group was treated with the Wendan decoction.Results:After 3 months of treatment,the triglycerides,cholesterol,HDL,fasting glucose in two groups were improved than before treatment(P<0.05).The effect of triglycerides and cholesterol in the TCM group were better than the western medicine group(P<0.01),the increase of HDL cholesterol in the TCM group was more significant than the western medicine group(P<0.05).Before treatment,bifidobacteria and lactobacillus in the TCM group and the Western medicine group were lower,and enterobacteria was higher than the normal control group.P<0.05.After 3 months of treatment,bifidobacteria and lactobacillus were increased in the TCM group and the Western medicine group,while enterobacteria was decreased,P<0.05.The increase of lactobacillus and bifidobacterium in the TCM group was more obvious than the western medicine group,P<0.05.Conclusion:Compared with metformin,the Wendan decoction shows a better advantage in improving lipid metabolism disorder,which may play a role by regulating intestinal flora.
出处
《中医临床研究》
2021年第13期99-102,共4页
Clinical Journal Of Chinese Medicine
基金
广东省中医药管理局项目(20201273)。
关键词
温胆汤
代谢综合征
奥氮平
肠道菌群
The Wendan decoction
Metabolic syndrome
Olanzapine
Intestinal flora
