摘要
目的探讨糖类抗原199(CA199)和血小板计数(PLT)变化与急性梗阻性化脓性胆管炎(AOSC)的关系。方法选择商丘市第一人民医院2019年1月至2020年5月收入90例AOSC患者,并选择我院同期健康体检者60例进行研究,观察两组入选者不同时期PLT、CA199水平,以及不同AOSC患者PLT、CA199水平,并分析PLT、CA199水平与AOSC患者之间的相关性。结果入院时两组PLT、CA199水平差异有统计学意义(308.65±34.41比319.55±30.14、80.64±8.65比30.47±4.21),入院后两组患者PLT、CA199水平明显下降,AOSC患者入院24 h、入院48 h的PLT低于健康体检者,AOSC患者入院24 h、入院48 h的CA199高于健康体检者(283.54±30.54比156.65±20.14、260.53±25.42比105.54±15.41、62.65±5.25比65.15±6.58、55.14±4.96比56.96±5.47),差异有统计学意义(P<0.05)。两组入院时PLT和CA199差异无统计学意义(P>0.05);AOSC患者入院24、48 h的PLT水平均高于伴有休克患者(308.65±34.41比319.55±30.14,290.54±30.54比305.65±24.62,280.53±25.42比292.74±20.32),入院24、48 h的CA199水平均低于伴有休克患者(80.64±8.65比30.47±4.21、73.15±6.58比23.41±4.54、65.96±5.47比20.54±2.65),差异有统计学意义(P<0.05)。PLT与AOSC患者病情严重程度呈负相关,CA199与AOSC患者病情严重程度呈正相关(P<0.05)。结论CA199和血小板计数可用于诊断AOSC,其中PLT水平越低,CA199水平越高,患者病情越严重,并发脓毒症性休克几率越高,入院后积极监测PLT、CA199水平水平,能较好预测监测患者病情。
Objective To study the correlation between the changes of carbohydrate antigen 199(CA199)and platelet count(PLT)and acute obstructive suppurative cholangitis(AOSC).Methods A total of 90 patients with AOSC in our hospital from January 2019 to May 2020 were selected,and 60 healthy people in our hospital during the same period were selected.PLT and CA199 levels in the two groups were determined in different periods.PLT and CA199 levels in different AOSC patients were observed,and the correlation between PLT,CA199 levels and AOSC was analyzed.Results At admission,the PLT and CA199 levels of the two groups were significantly different(308.65±34.41 vs.319.55±30.14、80.64±8.65 vs.30.47±4.21).After admission,the PLT and CA199 levels of the two groups were significantly decreased.The PLT of AOSC patients at 24 h and 48 h after admission was lower than that of healthy people.The CA199 of AOSC patients at 24 h and 48 h after admission was higher than that of healthy people(283.54±30.54 vs.156.65±20.14,260.53±25.42 vs.105.54±15.41,62.65±5.25 vs.65.15±6.58,55.14±4.96 vs.56.96±5.47),the difference was statistically significant(P<0.05).At admission,there was no significant difference in PLT and CA199 between the two groups(P>0.05);The PLT levels of AOSC patients at 24 h and 48 h after admission were higher than those with shock(308.65±34.41 vs.319.55±30.14,290.54±30.54 vs.305.65±24.62,280.53±25.42 vs.292.74±20.32),and the CA199 levels at 24 h and 48 h after admission were lower than those with shock(80.64±8.65 vs.30.47±4.21,73.15±6.58 vs.23.41±4.54,65.96±5.47 vs.20.54±2.65),the difference was statistically significant(P<0.05).PLT was negatively correlated with the severity of AOSC,and CA199 was positively correlated with the severity of AOSC(P<0.05).Conclusion CA199 and PLT can be used to diagnose AOSC.The lower the PLT level,the higher the CA199 level,the more serious the patient′s condition,and the higher the risk of septic shock.After admission,active monitoring of PLT and CA199 levels can well predict and monitor the patient′s condition.
作者
蔡锋
朱运海
赵杰
叶赛
Cai Feng;Zhu Yunhai;Zhao Jie;Ye Sai(Shangqiu First People′s Hospital/Xuzhou Medical University School of Gastrointestinal Hepatobiliary Surgery,Shangqiu 476100,China)
出处
《中华实验外科杂志》
CAS
北大核心
2021年第8期1563-1566,共4页
Chinese Journal of Experimental Surgery
基金
2020年度河南省医学科技攻关计划联合共建项目(LHGJ20200935)。
