摘要
目的探讨肺结核患者应用复方甘草酸苷(CG)治疗的临床效果。方法选取2018年9月至2020年5月鞍山市结核病医院收治的87例肺结核患者作为研究对象,随机分为A组(44例)与B组(43例)。B组予以常规抗结核治疗,即异烟肼+吡嗪酰胺+乙胺丁醇+利福平治疗,A组予以常规抗结核+CG治疗。比较两组治疗前与治疗后中医证候积分和血清Ⅲ型前胶原(PCⅢ)、血清透明质酸(HA)、早期分泌性抗原靶-6(ESAT-6)水平。结果治疗前,两组咳嗽、咳血、咳痰量、发热、盗汗、胸痛评分比较,差异无统计学意义(P>0.05);治疗后,A组咳嗽、咳血、咳痰量、发热、盗汗、胸痛评分低于B组,差异有统计学意义(P<0.05)。治疗前,两组血清HA、PCⅢ、ESAT-6比较,差异无统计学意义(P>0.05);治疗后,A组血清HA、PCⅢ、ESAT-6低于B组,差异有统计学意义(P<0.05)。结论肺结核患者采用CG治疗可改善血清学指标,缓解临床症状,疗效确切。
Objective To explore the effects of compound glycyrrhizin(CG)on pulmonary tuberculosis patients.Methods A total of 87 patients with CG admitted to Anshan Tuberculosis Hospital,from September 2018 to May 2020 were selected as the research objects and were randomly divided into group A(44 cases)and group B(43 cases).Group B received conventional anti-tuberculosis treatment,namely isoniazid+pyrazinamide+ethambutol+rifampicin,group A received conventional anti-tuberculosis+CG treatment.The scores of traditional Chinese medicine syndromes,serum typeⅢprocollagen(PCⅢ),serum hyaluronic acid(HA),and early secretory antigen target-6(ESAT-6)levels were compared between the 2 groups before and after treatment.Results Before treatment,there was no significant difference in the scores of cough,hemoptysis,sputum production,fever,night sweats,and chest pain between the 2 groups(P>0.05);after treatment,group A had cough,hemoptysis,sputum production,fever,and night sweats,the score of chest pain,which were lower than that of group B,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum HA,PCⅢ,ESAT-6 between the 2 groups,the difference was not statistically significant(P>0.05).After treatment,serum HA,PCⅢand ESAT-6 in group A were lower than those in group B,the difference was statistically significant(P<0.05).Conclusion The treatment of pulmonary tuberculosis patients with CG can improve the serum index,relieve the clinical symptoms,and have a definite effect.
作者
田越
李辉
李红
TIAN Yue;LI Hui;LI Hong(Tuberculosis Department,Anshan Tuberculosis Hospital,Liaoning Province,Anshan 114000,China)
出处
《中国药物经济学》
2021年第6期47-49,共3页
China Journal of Pharmaceutical Economics
关键词
肺结核
复方甘草酸苷
中医证候
血清学指标
Tuberculosis
Compound Glycyrrhizin
Symptom of Traditional Chinese medicine
Serological index
