摘要
癫痫作为一种古老的疾病,在全世界有广泛的发病人群,其对于个人、家庭、社会都有严重的负面影响。左乙拉西坦作为第二代抗癫痫药物,因其相对高安全性、药代动力学简单及与其他药物相互作用的发生率低等特点,在临床上广泛应用。虽然左乙拉西坦在控制癫痫发作方面疗效显著,但在使用过程中会出现多种不良反应,如头晕、共济失调,以及包括抑郁、焦虑、情绪不安甚至自杀等精神行为异常。该文主要就左乙拉西坦导致精神行为异常的可能机制、影响因素等方面进行综述,并对临床应用提出建议。
Epilepsy,as an ancient disease,develops in a wide range of populations all over the world,which has serious negative impacts on individuals,families,and society.As one of the second-generation antiepileptic drugs,levetiracetam is widely used in clinical practice because of its relatively high safety,simple pharmacokinetics,and low incidence of interaction with other drugs.Although levetiracetam is significantly effective in controlling epileptic seizure,it may cause various adverse reactions such as dizziness,ataxia,and mental and behavioral disorders including depression,anxiety,uneasiness,and even suicide.This article mainly reviews the possible mechanism of levetiracetam causing mental and behavioral disorders and its influencing factors;meanwhile,some suggestions for clinical application are provided.
作者
王麒淞
李杰
WANG Qi-Song;LI Jie(The First Clinical College of Xinxiang Medical University,Xinxiang,Henan 453100,China)
出处
《国际神经病学神经外科学杂志》
2021年第3期307-310,共4页
Journal of International Neurology and Neurosurgery
关键词
癫痫
左乙拉西坦
精神行为异常
epilepsy
levetiracetam
mentaland behavioral disorders
