摘要
吞噬细胞运动蛋白(engulfment and cell mobility,ELMO)家族是一类介导细胞吞噬和运动的跨膜蛋白质,其在进化上高度保守。近年研究表明ELMO的异常表达参与肝癌、卵巢癌、乳腺癌及神经胶质瘤等恶性肿瘤的侵袭和转移过程,具有潜在的肿瘤诊断及预后价值。全文就ELMO家族与肿瘤的发生发展关系作一论述,并探讨ELMO基因甲基化在肿瘤早期诊断中的作用。
Engulfment and cell mobility family is a class of transmembrane proteins that mediate cell phagocytosis and motility, and remain highly conserved throughout evolution. In recent years, studies have been indicated that the abnormal expression of ELMO is involved in the progression of invasion and metastasis of malignancies, including liver cancer, ovarian cancer, breast cancer and glioma. And it has potential diagnostic and prognostic value of tumors. This article reviews the relationship between ELMO family and the occurrence and development of tumors, and explores the potential values of ELMO methylation in the early diagnosis and prognasis of tumors.
作者
李勇瑜
宋健
LI Yong-yu;SONG Jian(Hainan Cancer Hospital,Haikou 570312,China)
出处
《肿瘤学杂志》
CAS
2021年第7期579-585,共7页
Journal of Chinese Oncology
基金
海南省科技厅社会发展重点研发项目(ZDYF2017118)。
关键词
吞噬细胞运动蛋白
恶性肿瘤
侵袭
转移
甲基化
engulfment and cell mobility
malignancy
invasion
metastasis
methylation
