摘要
目的探讨牛磺酸对冠心病(CHD)合并2型糖尿病(T2DM)患者行经皮冠状动脉栓塞术(PCI)术后再狭窄的防治作用。方法选取河南大学第一附属医院2018年1月至2020年1月收治的CHD合并T2DM患者140例,所有患者均实施PCI术。140例患者随机分为对照组(n=70)和观察组(n=70)。两组均采用常规治疗,观察组加用400 mg/d牛磺酸。两组均连续治疗6周。分析两组治疗前后三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、一氧化氮(NO)和内皮素-1变化情况。两组均随访6个月,收集两组冠状动脉造影变化及不良心血管事件发生情况。结果观察组治疗后三酰甘油、总胆固醇、低密度脂蛋白胆固醇及内皮素-1水平低于对照组(P<0.05);观察组治疗后高密度脂蛋白胆固醇以及NO水平高于对照组(P<0.05);观察组术后6个月最小管腔直径高于对照组(P<0.05);观察组术后6个月冠脉狭窄程度低于对照组(P<0.05);观察组不良心血管事件发生率低于对照组(P<0.05)。结论牛磺酸可降低CHD合并T2DM行PCI术患者低血脂水平,改善患者血管内皮功能,预防PCI术后再狭窄,具有较好的安全性。
【Objective】To investigate the preventive and therapeutic effect of taurine on restenosis after percutaneous coronary intervention(PCI)in patients with type 2 diabetes mellitus(T2DM)and coronary heart disease(CHD).【Methods】A total of 140 patients with CHD complicated with T2DM treated in our hospital from January 2018 to January 2020 were randomly divided into control group(n=70)and observation group(n=70).Both groups were treated with routine treatment,and the observation group was given taurine 400 mg/d.Both groups were treated for 6 weeks.The changes of triglyceride,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,nitric oxide(NO)and endothelin-1 in the two groups were analyzed before and after treatment.Both groups were followed up for 6 months,and the changes of coronary angiography and the incidence of adverse cardiovascular events were collected.【Results】After treatment,the levels of triglyceride,total cholesterol,LDL-C and endothelin-1 in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of HDL-C and NO in the observation group were higher than those in the control group(P<0.05).The minimum lumen diameter of the observation group was higher than that of the control group 6 months after operation(P<0.05).The degree of coronary stenosis in the observation group was lower than that in the control group 6 months after operation(P<0.05).The incidence of adverse cardiovascular events in the observation group was lower than that in the control group(P<0.05).【Conclusion】Taurine can reduce the level of hypolipidemia,improve vascular endothelial function and prevent restenosis after PCI in CHD combined with T2DM.
作者
翟小菊
刘瑞娜
曹倩
惠学志
ZHAI Xiaoju;LIU Ruina;CAO Qian;HUI Xuezhi(Department of Cardiology,the First Affiliated Hospital of Henan University,Kaifeng,Henan 475000,China)
出处
《中国医学工程》
2021年第8期6-9,共4页
China Medical Engineering
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200554)。
关键词
牛磺酸
冠心病
2型糖尿病
经皮冠状动脉栓塞术
再狭窄
taurine
coronary heart disease
type 2 diabetes mellitus
percutaneous coronary intervention
restenosis
