摘要
采用超高效液相色谱-串联质谱法(UPLC-MS/MS)测定了化妆品中丙烯酰胺含量,并对其进行了不确定度评定。根据JJF 1059.1—2012《测量不确定度评定与表示》建立测定化妆品中丙烯酰胺含量的计量学数学模型,分析和量化各不确定度分量。采用该方法检测的化妆品中丙烯酰胺的合成不确定度为0.033mg/kg,扩展不确定度为0.066mg/kg。实验测定的化妆品中丙烯酰胺含量结果为(0.502±0.066)mg/kg(k=2,置信概率P=95%)。评定结果表明,实验的不确定度主要由标准溶液配制和标准曲线拟合引入。
The content of acrylamide in cosmetics was determined by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC MS/MS),and the uncertainty was evaluated.According to JJF 1059.1—2012“Evaluation and Expression of Uncertainty in Measurement”,a metrological model for determination of acrylamide residues in cosmetics was established.And each component of uncertainty in the whole measuring process was analyzed and quantified.The combined uncertainty in the determination of acrylamide in cosmetics was 0.033mg/kg and the expanded uncertainty was 0.066mg/kg.The content of acrylamide in cosmetics was(0.502±0.066)mg/kg(k=2,confidence interval P=95%).The uncertainty of the method was mainly caused by standard solution preparation and calibration fitting.
作者
曹海荣
薛晓康
李晓宇
CAO Hai-rong;XUE Xiao-kang;LI Xiao-yu(School of Chemical and Environmental Engineering,Shanghai Institute of Technology,Shanghai 201418,China;Shanghai Research Institute of Chemical Industry Co.,Ltd,Shanghai 200062,China)
出处
《计量学报》
CSCD
北大核心
2021年第8期1101-1109,共9页
Acta Metrologica Sinica
基金
上海市化学品公共安全工程技术研究中心项目(18DZ2280700)。
