摘要
玻璃膜疣的形成是早期老年性黄斑变性(AMD)的主要标志之一。玻璃膜疣内的氧化磷脂(OxPLs)具有强促炎特性,其引发的氧化应激和炎症反应可引发视网膜色素上皮细胞死亡(凋亡、焦亡等)和脉络膜新生血管形成,即AMD的发病。焦亡又称炎性坏死,是OxPLs导致细胞死亡的主要方式之一。焦亡细胞释放的炎性因子又可反过来加重炎症反应,从而导致进一步的损害。而通过调节脂代谢,减少OxPLs内吞和增加胆固醇外流,就可能减轻炎症反应和减少细胞死亡,从而达到防治AMD的目的。因此,深入了解OxPLs、炎症以及焦亡在AMD发病中的作用,对于阐明AMD的发病机制以及寻找新的治疗措施具有重要的临床意义。
Drusen is one of the early hallmark changes of AMD.The oxidative stress and inflammatory reaction caused by oxidative phospholipids(OxPLs)in drusen can lead to retinal pigment epithelium(RPE)cell death(apoptosis,pyroptosis,etc.)and the formation of choroidal neovascularization,which is the pathogenesis of AMD.Pyroptosis,also known as inflammatory necrosis,is one of the main forms of OxPLs induced cell death.Proinflammatory factors released by pyroptic cells can in turn aggravate the inflammatory reaction,leading to further damage.In order to prevent AMD,inflammatory response and cell death may be reduced by regulating lipid metabolism,reducing OxPLs endocytosis and increasing cholesterol efflux.In-depth understanding effects of OxPLs,inflammation and RPE pyrosis in the pathogenesis of AMD in elucidate the pathogenesis of AMD and to seek new treatment measures has important clinical significance.
作者
吴桐
党宽荣
惠延年
杜红俊
Wu Tong;Dang Kuanrong;Hui Yannian;Du Hongjun(Department of Ophthalmology,Eye Institute of PLA,Xijing Hospital,The Air Force Medical University,Xi’an 710032,China)
出处
《中华眼底病杂志》
CSCD
北大核心
2021年第8期656-660,共5页
Chinese Journal of Ocular Fundus Diseases
基金
国家自然科学基金(81470654)
陕西省自然科学基金(2019SF-047)。
关键词
黄斑变性
清道夫受体
E类
细胞死亡
炎症
综述
Macular degeneration
Scavenger receptors,class E
Cell death
Inflammation
Review
