摘要
目的探讨术后调强放疗(IMRT)在喉癌治疗中的临床应用价值。方法根据治疗方案的不同将80例喉癌患者分为观察组(n=44)和对照组(n=36),对照组采用手术治疗,观察组在对照组基础上采用IMRT。比较两组患者炎症因子水平[白细胞介素(IL)-2、IL-4、肿瘤坏死因子-α(TNF-α)]、甲状腺功能指标[三碘甲状腺原氨酸(T_(3))、促甲状腺激素(TSH)、四碘甲状腺原氨酸(T_(4))]、纤溶状态指标[纤维蛋白原(FIB)、D-二聚体(D-D)]、凝血指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]、生活质量。结果治疗后,两组患者IL-2、IL-4和TNF-α水平均明显低于本组治疗前,差异均有统计学意义(P﹤0.01)。治疗后,两组患者TSH水平均明显高于本组治疗前,T_(3)和T_(4)水平均明显低于本组治疗前,差异均有统计学意义(P﹤0.01);且观察组患者TSH水平明显高于对照组,T_(3)和T_(4)水平均明显低于对照组,差异均有统计学意义(P﹤0.01)。治疗后,两组患者FIB和D-D水平均明显低于治疗前,且观察组均明显低于对照组,差异均有统计学意义(P﹤0.01)。治疗后,两组患者健康调查简表(SF-36)量表各维度评分均明显高于本组治疗前,且观察组患者SF-36量表中生理机能、生理职能、躯体疼痛、一般健康状况、精神健康评分均明显高于对照组,差异均有统计学意义(P﹤0.01)。结论术后IMRT在喉癌治疗中有较好的效果,可改善患者炎症因子水平、甲状腺功能、纤溶因子水平、生活质量,具有一定的临床应用价值。
Objective To investigate the effect of postoperative intensity modulated radiationtherapy(IMRT)in the treatment of laryngeal cancer.Method A total of 80 patients with laryngeal cancer were selected and divided into obser-vation group(n=44)and control group(n=36)according to the different treatment plan.The control group was given sur-gical treatment,and the observation group was given IMRT on the basis of the control group.The levels of inflammatory factors[interleukin(IL)-2,IL-4 and tumor necrosis factor-α(TNF-α)],thyroid function index[triiodothyronine(T_(3)),thy-roid stimulating hormone(TSH),tetraiodothyronine(T_(4))],fibrinolytic status index[fibrinogen(FIB),D-dimer(D-D)],co-agulation index[activated partial thromboplastin time(APTT),prothrombin time(PT)],quality of life were compared be-tween the two groups.Result After treatment,the levels of IL-2,IL-4 and TNF-αin the two groups were significantly lower than those before treatment(P<0.01).After treatment,the level of TSH in the two groups were significantly higher than those before treatment,the levels of T_(3) and T_(4) were significantly lower than those before treatment(P<0.01);the lev-el of TSH in the observation group was significantly higher than that in the control group,and the levels of T_(3) and T_(4) were significantly lower than those in the control group(P<0.01).After treatment,the levels of Fib and D-D in the two groups were significantly lower than those before treatment,and the levels of FFIB and D-D in the observation group were signif-icantly lower than those in the control group(P<0.01).After treatment,the scores of all dimensions of the Mos item short from health survey(SF-36)scale in the two groups were significantly higher than those before treatment,and the SF-36 scores of physiological function,physiological function,physical pain,general health and mental health in the observa-tion group were significantly higher than those in the control group,the differences were statistically significant(P<0.01).Conclusion Postoperative IMRT is effective in laryngeal cancer treatment,which can improve the level of inflammatory factors,thyroid function,fibrinolytic factors and quality of life.It has certain clinical application value.
作者
王娜
陈联
张微
WANG Na;CHEN Lian;ZHANG Wei(Department of Otolaryngology,Lishan Branch,Anshan Central Hospital,Anshan 114032,Liaoning,China)
出处
《癌症进展》
2021年第14期1466-1469,1480,共5页
Oncology Progress
关键词
调强放疗
喉癌
炎症因子
甲状腺功能
纤维蛋白原
D-二聚体
intensity modulated radiation therapy
laryngeal cancer
inflammatory factors
thyroid function
fibrino-gen
D-dimer
