摘要
目的了解广东省中山地区献血者酶联免疫吸附试验(ELISA)单试剂检测反应的情况,探讨有效的归队策略,以减少献血者流失。方法采用血站标准化信息管理系统回顾性分析2018年1月至2020年6月HBsAg、抗-HCV、HIV Ag/Ab、抗-TP单试剂检测反应性且核酸检测合格的献血者,经屏蔽6个月及以上,针对屏蔽项目进行归队再复查和再次献血后全面检测,统计其项目反应性分布情况及归队合格率、返回率,采用χ^(2)检验比较归队人群不同特征的差异性。结果本地区724名单试剂反应性献血者中,归队返回率为23.5%(170/724),合格率为58.2%(99/170),其中抗-HCV合格率最高,占76.5%(13/17);归队成功献血者再次献血返回率为41.4%(41/99),合格率为97.6%(40/41);归队献血者与未归队献血者的性别差异无统计学意义(P>0.05);归队献血者与未归队献血者年龄、献血次数比较,差异有统计学意义(P<0.05)。结论单试剂反应性献血者中存在假反应性,归队人群以重复献血者为主,现行的归队程序可防止经血传播的病原体漏检,但在献血者服务等方面仍需进一步完善和细化。
Objective To investigate the single reagent reaction of enzyme linked immunosorbent assay(ELISA)in blood donors in Zhongshan area of Guangdong Province,and to explore effective return strategy and measures to reduce blood loss.Methods Blood donors with HBsAg,anti-HCV,HIV Ag/Ab and anti-TP single reagents and qualified nucleic acid tests from January 2018 to June 2020 were retrospectively analyzed by using the standardized information management system of blood stations.After shielded for 6 months or more,the shielded items were rechecked and tested comprehensively after blood donation.The distribution of item reactivity,the qualified rate and the return rate of the shielded subjects were counted.The differences of different characteristics of the returnees were compared byχ^(2) test.Results Among the 724 list of reagent-reactive blood donors in the region,the return rate was 23.5%(170/724),and the pass rate was 58.2%(99/170).Among them,the anti-HCV pass rate was the highest,accounting for 76.5%(13/17).The return rate of re-donation of successful blood donors was 41.4%(41/99),and the pass rate was 97.6%(40/41).There was no difference between returned blood donors and unreturned blood donors(P>0.05).There were differences in age and frequency of blood donation between returned and unreturned blood donors(P<0.05).Conclusion False reactivity exists among single-agent reactive blood donors.The returnees are mainly repeat blood donors.The current return procedures can prevent the missed detection of blood-transmitted pathogens,but blood donor services still need to be further improved and refined.
作者
李乔
孙爱农
廖艳婷
LI Qiao;SUN Ainong;LIAO Yanting(Clinical Laboratory,Zhongshan Blood Center,Zhongshan 528400,China)
出处
《河南医学研究》
CAS
2021年第21期3869-3872,共4页
Henan Medical Research
关键词
献血者归队
单试剂反应性
酶联免疫吸附试验
血液安全
blood donor return
single reagent reaction
enzyme linked immunosorbent assay
blood safety
