摘要
目的研究苏州女性体检人群中HPV感染状况及亚型分布。方法采用实时荧光聚合酶链反应(PCR)技术,对2019年1月至2019年12月在苏州市体检中心体检的1846名女性的宫颈脱落细胞进行HPV检测,对相关数据进行统计分析。结果1)HPV感染率为14.52%(268/1846)。HPV的第1个感染高峰是17~34岁组(16.41%),第2个感染高峰是65岁以上组(20.93%),且60~64岁组就有明显的感染上升趋势(20.45%),60~64岁组与65岁以上组的HPV感染率均高于第1个高峰。所有年龄组比较,HPV感染率无统计学差异。2)40岁以下的受检女性占比较高(42.15%),随着年龄增加,HPV受检女性的比重在逐步下降,65以上岁组女性占比最低(2.33%),60~64岁组其次(2.38%)。3)71.64%的HPV感染为单一感染,28.35%为多重感染。50~54岁组单一感染率最高(82.26%),与17~34岁组相比,P<0.05,与其他组相比较,无统计学差异。60~64岁组、65岁以上组多重感染率最高,均为44.44%,分别与其他组比较,无统计学差异。4)感染最多的前五位高危型HPV亚型分别是HPV52(3.36%),HPV58(2.17%),HPV16(1.68%),HPV51(1.62%),HPV53(1.46%)。感染最多的低危型HPV亚型的是HPV81(1.03%)。其中,易合并多重感染的前5位高危型HPV亚型依次是HPV73、26、35、18、82。结论苏州地区HPV感染以单一感染居多(71.64%),50~54岁的女性比34岁以下的年轻女性更易单一感染。苏州地区体检女性所感染的HPV高危亚型分布依次为HPV52、58、16、51、53,存在地区差异性。苏州地区老年妇女的HPV检查意识不足,且HPV感染率不容乐观,应加强对老年妇女的健康宣教以及HPV筛查。
Objective:To study the HPV infection status and subtype distribution in Suzhou female physical examination population.Methods:Using real-time fluorescence polymerase chain reaction(PCR)technology,HPV detection was carried out on cervical exfoliated cells of 1846 women who underwent physical examination in Suzhou Physical Examination Center from January 2019 to December 2019,and the related data were statistically analyzed.Results:1)HPV infection rate was 14.52%(268/1846).The first infection peak of HPV is 16.41%in the group aged 17~34,and the second infection peak is 20.93%in the group aged over 65.The infection rate of HPV in the group aged 60~64 is higher than the first peak.There was no significant difference in HPV infection rate among all age groups.2)The proportion of women under 40 years old is relatively high(42.15%).With the increase of age,the proportion of women examined for HPV is gradually decreasing.The proportion of women over 65 years old is the lowest(2.33%),followed by those aged 60~64 years old(2.38%).3)71.64%of HPV infection is single infection and 28.35%is multiple infection.The single infection rate of 50~54 years old group was the highest(82.26%),compared with 17~34 years old group,P<0.05,and compared with other groups,there was no statistical difference.The multiple infection rates of 60~64 years old group and over 65 years old group were the highest,both of which were 44.44%,and there was no statistical difference compared with other groups.4)The top five high-risk HPV subtypes with the most infection are HPV52(3.36%),HPV58(2.17%),HPV16(1.68%),HPV51(1.62%)and HPV53(1.46%).HPV81(1.03%)was the most frequently infected low-risk HPV subtype.Among them,the top five high-risk HPV subtypes prone to multiple infections are HPV73,26,35,18 and 82 in turn.Conclusion:HPV infection in Suzhou is mostly single infection(71.64%),and women aged 50~54 are more likely to be single infection than young women under 34.The distribution of high-risk subtypes of HPV infected by women in physical examination in Suzhou was HPV52,58,16,51 and 53 in turn,with regional differences.The elderly women in Suzhou are not aware of HPV examination,and the infection rate of HPV is not optimistic.Health education and HPV screening should be strengthened for the elderly women.
作者
张彦
Zhang yan(Health Management Center, Suzhou Hospital Affiliated to Nanjing Medical University, Jiangsu Suzhou, 215008, China)
出处
《中外女性健康研究》
2021年第14期194-197,共4页
Women＇s Health Research
