摘要
目的:探讨腹腔热灌注化疗技术(HIPEC)对妇科恶性肿瘤伴恶性腹水患者的短期疗效。方法:选取广西南宁市第一人民医院肿瘤科收治的妇科恶性肿瘤伴恶性腹水患者共80例,按随机数字表法分为观察组和对照组,每组40例。对照组接受常规化疗及支持治疗,观察组在常规化疗及支持治疗基础上,利用热灌注机经导管在腹腔/盆腔灌注化学药物治疗;2个治疗周期后比较两组恶性腹水、血清肿瘤学指标[糖类抗原125(CA125)、糖类抗原15-3(CA153)、营养学指标[白蛋白(ALB)、血红蛋白(Hb)]、超敏C反应蛋白变化情况;利用健康调查简表(SF-36量表)比较两组生活质量及不良反应发生情况。结果:两组治疗后腹水量均较治疗前减少(P<0.05),且观察组腹水量明显少于对照组(P<0.05);治疗后观察组血清CA153、CA125水平明显低于对照组(P<0.05),血清ALB、Hb含量显著高于对照组(均P<0.05),超敏C反应蛋白明显低于对照组(P<0.05);观察组SF-36表各项目较对照组显著升高(P<0.05);且两组在不良反应方面未见明显差异(P>0.05)。结论:HIPEC可有效缓解妇科恶性肿瘤患者的恶性腹水,降低肿瘤学指标,升高营养学指标,提高患者生活质量,且未增加明显不良反应,是治疗妇科恶性肿瘤伴恶性腹水的一种有效手段。
Objective:To observe the short-term efficacy of intraperitoneal hyperthermic perfusion chemotherapy(HIPEC)in the treatment of gynecological malignant tumor with malignant ascites.Methods:A toll of 80 gynecological malignant tumor with malignant ascites patients were randomly divided into an observation group and a control group,with 40 cases in each group.The patients in the control group received routine chemotherapy and supportive treatment,while those in the observation group were treated as the control group with addition of hyperthermic perfusion machine via catheter.The malignant ascites,carbohydrate antigen(CA)153,CA125,albumin(ALB),hemoglobin(HB)and high sensitivity C-reactive protein were compared between the two groups after two treatment cycles.The quality of life(SF-36)and adverse reactions were compared as well.Results:After treatment,the amount of ascites was decreased in both groups(P<0.05),and the amount of ascites in the observation group was significantly less than that in the control group(P<0.05).After treatment,the levels of serum CA153,CA125 and high-sensitivity C-reactive protein in the observation group were significantly lower than those in the control group,while the serum ALB and Hb levels and SF-36 scores were significantly higher(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:HIPEC can effectively alleviate the malignant ascites of patients with gynecological malignant tumor,reduce the oncology index,elevate the nutritional index,improve the quality of life of patients,and do not increase adverse reactions.It is an effective method for the treatment of gynecological malignant tumor with malignant ascites.
作者
孙明辉
沈玲
陆建勋
Sun Minghui;Shen Ling;Lu Jianxun(Department of Oncology,The First People's Hospital of Nanning,Nanning 530021,China)
出处
《广西医科大学学报》
CAS
2021年第8期1569-1574,共6页
Journal of Guangxi Medical University
基金
广西壮族自治区卫生健康委员会自筹经费课题项目(No.Z20190848)。
关键词
热灌注化疗
妇科恶性肿瘤
恶性腹水
生活质量
hyperthermic perfusion chemotherapy
gynecological malignant tumor
malignant ascites
quality of life
