摘要
目的观察康莱特注射液联合化疗对非小细胞肺癌(Non-small cell lung carcinoma,NSCLC)中晚期患者肺功能和癌痛的影响。方法将我院80例NSCC中晚期患者随机分为观察组与对照组各40例。对照组采用化疗,观察组采用静脉滴注康莱特注射液联合化疗,比较两组患者的临床疗效、肺功能、癌痛程度及血清肿瘤标志物的水平。结果观察组患者总有效率高于对照组(P<0.05);治疗后,两组最大通气量(MVV)、用力肺活量(FVC)、1秒用力呼气容积(FEV1)、1秒率(FVC/FEV1)较治疗前升高,视觉疼痛模拟评分(VAS)较治疗前下降,且观察组MVV、FVC、FEV1、FEV1/FVC高于对照组,观察组VAS评分低于对照组(P<0.05);两组神经烯醇化酶(NSE)、糖类抗原125(CA125)、癌胚抗原(CEA)水平较治疗前下降,且观察组NSE、CA125、CEA水平低于对照组(P<0.05)。结论康莱特注射液联合化疗治疗NSCLC中晚期患者的疗效满意,能提高肺功能,降低癌痛,降低血清肿瘤标志物的表达。
Objective To observe the effects of Kanglaite Injection adjuvant chemotherapy on lung function and cancer pain in patients with non-small lung cell carcinoma(NSCLC) in the middle and advanced stages.Methods Eighty patients with advanced NSCLC were divided into observation group and control group with 40 cases each.Control group was treated with chemotherapy,and observation group was treated with Kanglaite Injection as adjuvant chemotherapy.The clinical efficacies,lung function,degree of cancer pain and serum tumor marker levels were compared between the two groups.Results The total effective rate of observation group was higher than control group(P<0.05).After treatment,the maximal ventilatory volume(MVV),forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FVC/FEV1 increased in both groups compared to before treatment;Visual analogue scale(VAS) scores were lower than before treatment;MVV,FVC,FEV1,FEV1/FVC of observation group were higher than those of control group,and the VAS score of observation group was lower than that of control group(P<0.05),the levels of Neuroenolase(NSE),Carbohydrate Antigen 125(CA125),and Carcinoembryonic Antigen(CEA) in both groups were lower than before treatment;and were lower in observation group than those in control group(P<0.05).Conclusion Kanglaite Injection adjuvant chemotherapy is satisfactory in treatment of patients with advanced NSCLC,which can improve lung function,reduce cancer pain,and the expression of serum tumor markers.
作者
周娟
付萍
韩慧
王宝中
狄曼曼
宋玉军
ZHOU Juan;FU Ping;HAN Hui;WANG Baozhong;DI Manman;SONG Yujun(Liaocheng People's Hospital of Shandong Province,Liaocheng 252000;Dongchangfu District Hospital of TCM,Liaocheng 252000)
出处
《湖北中医药大学学报》
2021年第4期34-36,共3页
Journal of Hubei University of Chinese Medicine
基金
吴阶平医学基金会科研专项资助项目(项目编号:2020-3206750)。
关键词
非小细胞癌
康莱特
化疗
肺功能
癌痛
non-small cell lung carcinoma
Kanglaite Injection
chemotherapy
lung function
cancer pain
