摘要
目的:探讨新生儿急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患儿血清中Clara细胞分泌蛋白16(Clara cell secretory protein16,CC16)、肺表面活性蛋白A(pulmonary surfactant protein A,SP-A)的变化及其对ARDS严重程度的评估意义。方法:收集2016年1月至2018年11月西安市儿童医院新生儿重症监护室(NICU)住院的需行机械通气治疗的30例ARDS新生儿作为观察组,分为3个亚组:轻度组12例,中度组10例,重度组8例;对照组为同期正常新生儿30例。ELISA法检测患儿血清CC16及SP-A水平,比较不同组以及亚组间血清CC16、SP-A水平差异。结果:ARDS组血清CC16、SP-A分别为(59.35±3.67)mg/L、(75.38±6.27)mg/L,高于对照组[分别为(11.26±1.32)mg/L、(18.15±2.69)mg/L],两组差异有统计学意义(P<0.05)。ARDS亚组间血清CC16、SP-A随病情加重而升高,组间比较差异有统计学意义(P<0.05),轻度、中度、重度亚组中CC16分别为(38.27±16.01)mg/L、(51.25±15.63)mg/L、(84.76±13.12)mg/L,SP-A分别为(47.02±7.18)mg/L、(73.12±7.98)mg/L、(96.45±12.50)mg/L。随着ARDS严重程度加重,血清CC16和SP-A水平升高(P<0.05)。结论:新生儿ARDS血清CC16、SP-A升高,且与病情严重程度相关,未来可能作为新生儿ARDS病情严重程度评估的指标。
Objective To investigate the clinical significance of changes of serum Clara cell secretory protein(CC16)and pulmonary surfactant protein A(SP-A)in neonates with acute respiratory distress syndrome(ARDS).Methods The data of 30 neonates with ARDS who needed mechanical ventilation in neonatal intensive care unit of Xi′an Children′s Hospital from January 2016 to November 2018 were collected as observation group,including 12 cases in mild group,10 cases in moderate group and 8 cases in severe group.The data of healthy newborns during the same period were taken as control group.The serum levels of CC16 and SP-A were detected by ELISA.The serum levels of CC16 and SP-A among different groups were compared.Results The levels of serum CC16 and SP-A in ARDS group were(59.35±3.67)mg/L and(75.38±6.27)mg/L respectively,(11.26±1.32)mg/L and(18.15±2.69)mg/L in healthy group.The difference was significant(P<0.05).And the differences of serum CC16 and SP-A levels among different degree ARDS groups were significant(P<0.05).The levels of serum CC16 in mild,moderate and severe subgroup were(38.27±16.01)mg/L,(51.25±15.63)mg/L,(84.76±13.12)mg/L and SP-A were(47.02±7.18)mg/L,(73.12±7.98)mg/L,(96.45±12.50)mg/L,which increased with disease severity.Conclusion Serum CC16 and SP-A are increased and correlated with the severity of neonatal ARDS,which may be used as the index for evaluating the severity of neonatal ARDS in the future.
作者
陈璐
魏家凯
安瑶
张婕
赵玉娟
Chen Lu;Wei Jiakai;An Yao;Zhang Jie;Zhao Yujuan(Department of Neonatology,Xi′an Children′s Hospital,Xi′an Jiaotong University,Xi′an 710003,China)
出处
《中国小儿急救医学》
CAS
2021年第8期697-700,共4页
Chinese Pediatric Emergency Medicine
基金
陕西省社会发展科技攻关项目(2016SF-273)。
