摘要
目的:探讨乌灵胶囊联合失眠认知行为疗法治疗高龄慢性失眠症患者的疗效。方法:纳入2015年6月至2020年6月于中国人民解放军联勤保障部队第九〇一医院就诊的高龄慢性失眠症患者110例作为研究对象,采用随机数字表法分为观察组和对照组,每组55例。观察组患者采用乌灵胶囊联合失眠认知行为疗法治疗,对照组患者采用失眠认知行为疗法治疗,每组患者治疗8周。观察两组患者的临床疗效,失眠严重指数量表(insomnia severity index,ISI)评分,匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)评分、蒙特利尔认知评测量表(Montreal cognitive assessment,MoCA)评分、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分和汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分,血清P物质(SP)、神经肽Y(NPY)和5-羟色胺(5-HT)水平。结果:观察组患者的总有效率为78.18%(43/55),明显高于对照组的60.00%(33/55),差异有统计学意义(P<0.05)。两组患者治疗后的ISI评分、SP水平、PSQI评分、MoCA评分、HAMD评分和HAMA评分均较治疗前明显降低,观察组患者降低程度更明显,差异均有统计学意义(P<0.05)。两组患者治疗后的NYP、5-HT水平均较治疗前明显升高,观察组患者升高程度更明显,差异均有统计学意义(P<0.05)。结论:乌灵胶囊联合失眠认知行为疗法治疗高龄慢性失眠症患者的疗效明显,且可以改善认知功能、焦虑和抑郁情况。
OBJECTIVE: To probe into the efficacy of Wuling capsules combined with cognitive behavior therapy in the treatment of elderly chronic insomnia. METHODS: Totally 110 elderly patients with chronic insomnia admitted into the 901 th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army from Jun. 2015 to Jun.2020 were extracted to be divided into the observation group and the control group via the random number table,with55 cases in each group. The observation group was treated with Wuling capsules combined with cognitive behavior therapy,while the control group received cognitive behavior therapy,and both groups were treated for 8 weeks. The clinical efficacy,insomnia severity index( ISI) score,Pittsburgh sleep quality scale( PSQI) score,Montreal cognitive assessment scale( Mo CA) score,Hamilton depression scale( HAMD) score and Hamilton anxiety scale( HAMA) score,serum substance P( SP),neuropeptide Y( NPY) and 5-hydroxytryptamine( 5-HT) levels of two groups were observed.RESULTS: The total effective rate of the observation group was 78. 18%( 43/55),significantly higher than that of the control group( 60. 00%,33/55),the difference was statistically significant( P<0. 05). The levels of ISI,SP,scores of PSQI,Mo CA,HAMD and HAMA decreased after treatment in both groups compared with those before treatment,and the degree of reduction was more significant in the observation group,the difference was statistically significant( P<0. 05). The levels of NYP and 5-HT in both groups after treatment were significantly higher than those before treatment,and the degree of increase was more significant in the observation group,the difference was statistically significant( P<0. 05). CONCLUSIONS: The efficacy of Wuling capsules combined with cognitive behavioral therapy in the treatment of chronic insomnia in the elderly is significant,which can improve the cognitive function,anxiety and depression.
作者
李月芳
江伟
LI Yuefang;JIANG Wei(Cadre Ward,the 901th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army,Anhui Hefei 230031,China)
出处
《中国医院用药评价与分析》
2021年第8期948-950,954,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
2021年安徽省重点研究与开发计划(第一批)立项项目(No.202104j07020002)。
关键词
乌灵胶囊
认知行为疗法
高龄
慢性失眠症
Wuling capsules
Cognitive behavioral therapy
Elderly
Chronic insomnia
