摘要
目的分析克罗米芬与来曲唑在多囊卵巢综合征临床治疗中的应用价值。方法以我院于2019年3月—2020年1月期间收治的114例多囊卵巢综合征患者为研究对象,结合患者的入院时间先后顺序以及57例单组区间条件分为对照组、研究组;对照组院内的治疗方案为克罗米芬,研究组院内的治疗方案为来曲唑;比对分析两组患者治疗后的卵泡成熟时间、卵泡成熟数、子宫内膜厚度、治疗前后血激素水平以及排卵率、生化妊娠率、临床妊娠率。结果研究组患者的卵泡成熟时间与对照组基本等同,差异无统计学意义(P>0.05),但其卵泡成熟数、子宫内膜厚度值均大于对照组,差异有统计学意义(P<0.05);治疗前,两组患者的血激素水平基本趋同,即差异无统计学意义(P>0.05);治疗后研究组患者的LH、FSH与T水平与对照组的进行比较,数据值均较小,组间差异有统计学意义(P<0.05);研究组患者的排卵率、生化妊娠率以及临床妊娠率均高于对照组,差异有统计学意义(P<0.05)。结论相对比克罗米芬而言,来曲唑在多囊卵巢综合征临床治疗中的应用价值更高,可降低生殖激素浓度,改善患者的子宫内膜厚度,促进卵泡成熟,提高患者的排卵率,为患者的临床妊娠创造较好的条件。
Objective To analyze the application value of clomiphene and letrozole in the clinical treatment of polycystic ovary syndrome.Methods 114 cases of polycystic ovary syndrome patients admitted to our hospital from March 2019 to January 2020 were taken as the research objects,combined with the time sequence of admission and 57 cases of single-group interval conditions were divided into control group and study group;the treatment plan in the control group was clomiphene,the treatment plan in the study group was letrozole;comparison and analysis of the follicular maturation time,the number of follicles,the thickness of the endometrium,and the blood hormone levels before and after treatment in the two groups And ovulation rate,biochemical pregnancy rate,clinical pregnancy rate.Results The follicle maturation time of the study group was basically the same as that of the control group(P>0.05),but the number of follicle maturation and endometrial thickness were greater than those of the control group.The difference was statistically significant(P<0.05);before treatment,the blood hormone levels of the two groups were basically the same,that is,the difference between the groups was not statistically significant(P>0.05);after treatment,the LH,FSH,and T levels of the study group were compared with those of the control group,and the data values were all smaller.The statistical significance of the difference was established(P<0.05);the ovulation rate,biochemical pregnancy rate and clinical pregnancy rate of the study group were higher than those of the control group,and the statistical significance of the difference was established(P<0.05).Conclusion Compared with clomiphene,letrozole has a higher application value in the clinical treatment of polycystic ovary syndrome.It can reduce the concentration of reproductive hormones,improve the thickness of the patient’s endometrium,promote follicle maturation,and increase the ovulation rate of patients,to create better conditions for patients'clinical pregnancy.
作者
程华英
CHENG Huaying(Department of Obstetrics and Gynecology,Wuhan Kangjian Maternity and Infant Hospital,Wuhan Hubei 430000,China)
出处
《中国继续医学教育》
2021年第27期135-138,共4页
China Continuing Medical Education
关键词
多囊卵巢综合征
克罗米芬
来曲唑
卵泡成熟数
排卵率
临床妊娠率
polycystic ovary syndrome
G'Finn
Letrozole
mature follicle number
ovulation rate
clinical pregnancy rate
