摘要
关黄柏主要含有生物碱、内酯、酚酸、苯丙素等多种类型成分,具有抗炎、抗菌、抗癌、降血糖、降血压、免疫调节等药理活性。关黄柏中尤以生物碱类成分最具代表性,结构类型多样且具有较好的药理活性,一直以来备受关注。对关黄柏的化学成分及其提取方法、药理活性、临床应用和质量评价进行总结,并重点阐述关黄柏生物碱类成分的结构类型和药理作用,为关黄柏质量控制和进一步开发利用提供参考。
Phellodendri Amurensis Cortex(PAC),mainly containing alkaloids,lactones,phenolic acids,and phenylpropanoids,has the pharmacological activities of anti-inflammation,antibiosis,anticancer,blood glucose lowering,blood pressure lowering,immune regulation,etc.Alkaloids,the most representative constituents in PAC,have various structure types and satisfying pharmacological activities.In this paper,the chemical constituents,extraction methods,pharmacological effects,clinical application,and quality evaluation of PAC were summarized,and the structure types and pharmacological effects of alkaloids of PAC were emphatically expounded,which provided a reference for the quality control and further development and utilization of PAC.
作者
冯媛
牛敏格
张清清
FENG Yuan;NIU Min-ge;ZHANG Qing-qing(College of Pharmacy,Hebei University of Chinese Medicine,Shijiazhuang 050200,China;Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province,Shijiazhuang 050200,China)
出处
《中国现代中药》
CAS
2021年第8期1486-1498,共13页
Modern Chinese Medicine
基金
河北省中医药管理局科研计划项目(2019084)
河北省大学生创新创业训练计划项目(S201914432037)
河北中医学院博士科研基金项目(BSZ2018004)
河北中医学院优秀青年教师基础研究计划项目(YQ2018008)。
关键词
关黄柏
生物碱
内酯
酚酸
苯丙素
药理活性
临床应用
质量评价
PhellodendriAmurensis Cortex
alkaloids
lactones
phenolic acids
phenylpropanoids
pharmacological activity
clinical application
quality evaluation
