摘要
目的:评价合作药物治疗管理(CDTM)模式在肿瘤营养规范化治疗中的临床应用效果。方法:取亳州市人民医院肿瘤营养不良患者90例,随机分为2组,每组45例。对照组采用五阶梯营养治疗法,干预组在对照组的治疗基础上联合CDTM模式干预。比较2组肿瘤患者综合营养(PG-SGA)评分、总热量及蛋白质摄入量、生活质量(QOL)评分、不良反应发生率、住院时间以及营养治疗成本。结果:治疗后,2组PG-SGA评分均较治疗前减少(P<0.01),且干预组PG-SGA评分低于对照组(P<0.01);2组首日总热量及蛋白质摄入量比较差异无统计学意义(P>0.05),但干预组蛋白质摄入量高于对照组(P<0.05);治疗后,2组QOL评分均显著高于治疗前(P<0.01),且干预组高于对照组(P<0.01);治疗后干预组恶心、呕吐、腹胀、腹泻不良反应发生率均低于对照组(P<0.05),头晕、乏力、皮疹、感染不良反应发生率2组差异无统计学意义(P>0.05);住院天数、住院总费用、检查费用、总药物费用2组差异均无统计学意义(P>0.05)。结论:CDTM模式应用于肿瘤营养规范化治疗有助于改善患者的营养状态,提高患者生活质量,降低不良反应发生率和住院成本,在肿瘤营养规范化治疗药学服务过程中发挥积极的作用。
OBJECTIVE To evaluate the clinical effect of collaborative drug therapy management(CDTM)model in the standardized treatment of tumor nutrition.METHODS A total of 90 tumor patients with malnutrition were randomly divided into two groups of intervention and control(n=45 each).The control group received five-step nutritional therapy while the intervention group additional CDTM mode intervention.Patient-generated subjective global assessment(PG-SGA)score,total calorie and protein intake,quality-of-life(QOL)score,incidence of adverse reactions,hospital stay and cost of nutritional therapy were compared between two groups.RESULTS After therapy,PG-SGA score declined in both groups compared with that pre-therapy(P<0.01)and PG-SGA score was lower in intervention group than that in control group(P<0.01).No significant inter-group difference existed in total calorie or protein intake at Day 1(P>0.05).However,protein intake of intervention group was higher than that of control group(P<0.05).After therapy,QOL scores of both groups were significantly higher than those pre-therapy(P<0.01)and intervention group was higher than control group(P<0.01).After therapy,the incidence of adverse reactions such as nausea,vomiting,abdominal distension and diarrhea was lower in intervention group than that in control group(P<0.05).Yet the incidence of adverse reactions such as dizziness,fatigue,rash and infection showed no statistically significant inter-group difference(P>0.05).Hospital stay,hospitalization expense and examination/drug cost showed no statistically significant inter-group difference(P>0.05).CONCLUSION For standardized treatment of tumor nutrition,application of CDTM model can maintain the nutritional status,improve the quality-of-life of patients and lower the incidence of adverse reactions and hospitalization expense.CDTM model plays an active role in the pharmaceutical care process of standardized treatment of tumor nutrition.
作者
吴炜
梁海
杨淼
程刚
陈方
冯翠影
蒋祥德
WU Wei;LIANG Hai;YANG Miao;CHENG Gang;CHEN Fang;FENG Cui-ying;JIANG Xiang-de(Department of Pharmacy,Municipal People's Hospital,Anhui Bozhou 236800,China;Department of Oncology,Municipal People's Hospital,Anhui Bozhou 236800,China)
出处
《中国医院药学杂志》
CAS
北大核心
2021年第17期1785-1790,共6页
Chinese Journal of Hospital Pharmacy
基金
亳州市人民医院院级科研项目(编号:By202014)
亳州市人民医院三新项目(编号:2020YB-58)。
关键词
合作药物治疗管理
肿瘤
营养规范化治疗
临床药学服务
collaborative drug therapy management(CDMT)
tumor
nutrition-standardized therapy
clinical pharmacy services
