摘要
Multiple sclerosis(MS)is a chronic inflammatory demyelinating disease of the central nervous system(CNS).Inflammation in MS is characterized by infiltration of peripheral immune cells into the CNS,especially in the meninges.^([1-4])The infiltration into meninges,which has been referred to as tertiary lymphoid tissues(TLTs),is a likely first step preceding infiltration into the CNS parenchyma.These invading autoreactive immune cells destroy myelin,the insulation surrounding neuronal axons,and cause demyelination in subpial and cortical areas,promoting disease pathogenesis.Experimental autoimmune encephalomyelitis(EAE).
