摘要
目的观察“木郁达之”理论治疗甲状腺癌术后患者的临床效果。方法选取2019年5月至2020年11月于辽宁中医药大学附属医院住院部收治的64例甲状腺癌术后患者,按照随机数字表法分为观察组和对照组,各32例。观察组男15例,女17例,年龄(41.21±10.22)岁;对照组男13例,女19例,年龄(40.72±10.41)岁。对照组给予左甲状腺素钠片,在对照组基础上观察组基于“木郁达之”理论给予疏肝理气、化痰散结中药加减。两组患者疗程均为28 d。观察两组患者的总有效率及治疗前后三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)、TSH受体抗体(TRAb)、甲状腺球蛋白(Tg)等甲状腺功能指标以及卡氏(KPS)功能状态评分。结果治疗后,观察组总有效率为90.63%(29/32),高于对照组68.75%(22/32),差异有统计学意义(χ^(2)=4.730,P<0.05)。观察组治疗后FT3、FT4水平分别为(3.49±0.18)pmol/L、(21.60±3.41)pmol/L,均显著高于对照组(3.06±0.57)pmol/L、(19.73±3.73)pmol/L,TSH水平为(1.21±0.57)μIU/ml,显著低于对照组(1.47±0.43)μIU/ml,差异均有统计学意义(均P<0.05)。观察组治疗后TgAb、TRAb、TPOAb、Tg水平分别为(37.42±14.72)IU/ml、(38.45±10.98)IU/L、(60.43±20.76)IU/ml、(0.15±0.09)μg/L,均低于对照组(42.63±13.21)IU/ml、(40.76±10.39)IU/L、(65.34±27.19)IU/ml、(0.19±0.05)μg/L,差异均有统计学意义(均P<0.05)。观察组治疗后KPS评分为(91.25±2.62)分,显著高于对照组(89.17±1.03)分,差异有统计学意义(P<0.05)。结论“木郁达之”理论治疗甲状腺癌术后患者具有较好的疗效,不仅可以改善FT3、FT4、TSH、TgAb、TPOAb、TRAb、Tg等甲状腺功能客观指标,还可以提高患者生存质量。
Objective To observe the clinical effect of"Mu Yu Da Zhi"theory in the treatment of patients after thyroid cancer surgery.Methods A total of 64 patients after thyroid cancer surgery who were admitted to the inpatient department of Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from May 2019 to November 2020 were selected and were divided into an observation group and a control group according to the random number table method,with 32 cases in each group.In the observation group,there were 15 males and 17 females,with an age of(41.21±10.22)years old;in the control group,there were 13 males and 19 females,with an age of(40.72±10.41)years old.The control group was given levothyroxine sodium tablets,and the observation group was given traditional Chinese medicines for soothing the liver and regulating Qi,reducing phlegm and dissipating masses based on the theory of"Mu Yu Da Zhi"on the basis of the control group.The course of treatment for both groups was 28 days.The total effective rates,and triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TgAb),TSH receptor antibody(TRAb),thyroglobulin(Tg)in thyroid function indexes,and KPS functional status scores before and after the treatment of two groups were observed.Results After the treatment,the total effective rate in the observation group was 90.63%(29/32),which was higher than that in the control group[68.75%(22/32)],with a statistically significant difference(χ^(2)=4.730,P<0.05).The levels of FT3 and FT4 in the observation group after the treatment were(3.49±0.18)pmol/L and(21.60±3.41)pmol/L,respectively,which were significantly higher than those in the control group[(3.06±0.57)pmol/L and(19.73±3.73)pmol/L],and the TSH level was(1.21±0.57)μIU/ml,which was significantly lower than that in the control group[(1.47±0.43)μIU/ml],with statistically significant differences(all P<0.05).The levels of TgAb,TRAb,TPOAb,and Tg in the observation group after the treatment were(37.42±14.72)IU/ml,(38.45±10.98)IU/L,(60.43±20.76)IU/ml,and(0.15±0.09)μg/L,respectively,which were significantly lower than those in the control group[(42.63±13.21)IU/ml,(40.76±10.39)IU/L,(65.34±27.19)IU/ml,and(0.19±0.05)μg/L],with statistically significant differences(all P<0.05).The KPS score of the observation group after the treatment was(91.25±2.62)points,which was significantly higher than that of the control group[(89.17±1.03)points],with a statistically significant difference(P<0.05).Conclusion"Mu Yu Da Zhi"theory has a good effect in the treatment of patients after thyroid cancer surgery,which can improve the objective indicators of thyroid function such as FT3,FT4,TSH,TgAb,TPOAb,TRAb,and Tg,and improve the patients'quality of life.
作者
于王子
金鹤
李晓旭
Yu Wangzi;Jin He;Li Xiaoxu(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处
《国际医药卫生导报》
2021年第18期2840-2844,共5页
International Medicine and Health Guidance News
基金
国家“十二五”科技支撑计划项目(2014BAI10B00)。
关键词
木郁达之
甲状腺癌
临床疗效
Mu Yu Da Zhi
Thyroid cancer
Clinical efficacy
