摘要
目的建立新精神活性物质(new psychoactive substance,NPS)盐型测定的离子色谱分析方法。方法建立离子色谱法分析NPS样品中6种有机酸根离子(乙酸根、酒石酸根、马来酸根、草酸根、富马酸根、柠檬酸根)和5种无机阴离子(氟离子、氯离子、硝酸根离子、硫酸根离子、磷酸根离子)的定性和定量分析方法。采用该方法对222份缴获NPS样品(103份含合成大麻素类,81份含卡西酮类,44份含苯乙胺类,12份含色胺类,7份含苯环利啶类,6份含哌嗪类,2份含氨基茚满类,26份含芬太尼类,43份含其他类)中的盐型进行分析。结果各阴离子在相应的线性范围内线性良好,相关系数(r)均大于0.999,检出限为0.01~0.05mg/L,定量限为0.1~0.5mg/L。合成大麻素类样品中,除(4-苄基哌嗪-1-基)[1-(5-氟戊基)-1H-吲哚-3-基]甲酮(5F-BEPIRAPIM)为盐酸盐外,其余102份均为碱型;81份卡西酮类、44份苯乙胺类、7份苯环利啶类、2份氨基茚满类样品的盐型均为盐酸盐;色胺类样品的盐型包括碱型、盐酸盐、富马酸盐、草酸盐4种;哌嗪类样品的盐型包括盐酸盐和碱型2种;芬太尼类和其他类样品的盐型包括碱型、盐酸盐、柠檬酸盐3种。结论采用离子色谱法对NPS样品的盐型进行分析,简单、准确、高效,使得NPS定性和定量结论更加科学、严谨。
Objective To establish an ion chromatography method for the salt form determination of new psychoactive substances(NPS).Methods The method of conducting qualitative and quantitative analysis of six types of organic acid ions(acetate ion,tartrate ion,maleate ion,oxalate ion,fumarate ion,citrate ion)and five types of inorganic anions(fluoride ion,chloride ion,nitrate ion,sulfate ion,phosphate ion)in NPS sample by ion chromatography was developed.The salt forms of 222 seized NPS samples(103 samples with synthetic cannabinoids,81 samples with cathinones,44 samples with phenylethylamines,12 samples with tryptamines,7 samples with phencyclidines,6 samples with piperazines,2 samples with aminoindenes,26 samples with fentanyls and 43 samples with other types of NPS)were analyzed by this method.Results Each anion had good linearity in the corresponding linear range,the correlation coefficients(r)were greater than 0.999,the limits of detection were 0.01-0.05 mg/L,and the limits of quantitative were 0.1-0.5 mg/L.Except that 5F-BEPIRAPIM was hydrochloride,the salt forms of the other 102 synthetic cannabinoids were all base.The salt form of 81 cathinone samples,44 phenylethylamine samples,7 phencyclidine samples and 2 aminoindene samples were all hydrochloride.The salt forms of tryptamine samples included base,hydrochloride,fumarate and oxalate.The salt forms of piperazine samples included base and hydrochloride.The salt forms of fentanyl samples and samples of other types included base,hydrochloride and citrate.Conclusion Ion chromatography is a simple,accurate and efficient method for determining the salt form of NPS samples,which makes the qualitative and quantitative conclusions of NPS more scientific and rigorous.
作者
陈月猛
花镇东
刘翠梅
贾薇
王燕
刘杉
CHEN Yue-meng;HUA Zhen-dong;LIU Cui-mei;JIA Wei;WANG Yan;LIU Shan(Key Laboratory of Drug Monitoring and Control,Drug Intelligence and Forensic Center,Ministry of Public Security,Beijing 100193,China;Drug Control Detachment of Guiyang Public Security Bureau,Guiyang 550081,China;Department of Investigation,Guizhou Police College,Guiyang 550005,China)
出处
《法医学杂志》
CAS
CSCD
2021年第4期500-504,共5页
Journal of Forensic Medicine
基金
国家重点研发计划资助项目(2016YFC0800903)
贵州省科技厅科技支撑项目(黔科合支撑[2021]一般529)。
关键词
法医学
毒物分析
新精神活性物质
阴离子交换色谱法
有机酸根离子
阴离子
盐型
forensic medicine
toxicological analysis
new psychoactive substance
anion exchange chromatography
organic acid ion
anion
salt form
