摘要
目的:应用静息态功能磁共振(fMRI)的方法探索耳穴电针改善原发性失眠(PI)日间思睡症状的脑效应机制。方法:纳入21例PI患者进行4周经皮耳穴电针治疗,于首次治疗前后进行磁共振检查,4周治疗前后进行爱泼沃斯思睡量表(ESS)评估;观察PI患者治疗前后ESS变化与低频振荡振幅(ALFF)、比率低频振幅(fALFF)、局部一致性(ReHo)变化之间的关系。结果:治疗4周后,PI患者ESS较治疗前显著降低(P<0.05);双额上回、右额中回、右背侧前扣带回的ALFF,双顶下回、双缘上回、右角回的fALFF,双额上回及右辅助运动区、右背侧前、中扣带回的ReHo与ESS改善呈正相关。结论:经皮耳穴电针可改善PI患者思睡症状,首次治疗前后负责心理、认知、执行控制的多个脑区fMRI指标与治疗4周后的思睡症状改善程度具有相关性。
Objective:To explore the brain mechanism of curing daytime sleepiness of transcutaneous auricular electroacupuncture in patients with primary insomnia by means of rest-state functional Magnetic Resonance Imaging(rs-fMRI).Methods:Twenty one patients with primary insomnia was recruited,all of them received the therapy of stimulating the auricular acupoint for 4 weeks,and the patients were evaluated with Epworth sleepiness scale(ESS)before and after treatment.Magnetic resonance examination was performed before and after the first treatment.And after 4 weeks of treatment.Relationship between the changes of ESS and the changes of functional magnetic resonance were observed.Results:ESS was significantly decreased after 4-week treatment(P<0.05).There were changes positively correlated with the ESS improvement,they were the low-frequency amplitude of bilateral superior frontal gyrus,right middle frontal gyrus and right dorsal anterior cingulate gyrus,the fractional amplitude of low frequency fluctuation of bilateral inferior parietal lobule,bilateral superior margin gyrus,and right angle gyrus,the regional homogeneity of bilateral superior frontal gyrus,the right supplementary motor area and the dorsal anterior and medial cingulate gyrus.Conclusion:Electroauricular acupuncture can improve the symptoms of daytime sleepiness in patients with primary insomnia.Fuctional changes after the first treatment in multiple brain regions responsible of emotion,cognition and execution were relative to the improvement.
作者
何家恺
王处渊
方继良
高德强
王俊英
陈丽梅
郭春蕾
王智
孙继飞
贾宝辉
荣培晶
HE Jia-kai;WANG Chu-yuan;FANG Ji-liang;GAO De-qiang;WANG Jun-ying;CHEN Li-mei;GUO Chun-lei;WANG Zhi;SUN Ji-fei;JIA Bao-hui;RONG Pei-jing(Institute of Acupuncture and Moxibustion,Chinese Academy of Chinese Medical Sciences,Beijing 100700,China;Guang’anmen Hospital,Chinese Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第8期4637-4641,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点研发计划(No.2018Y FC1705800)
国家自然科学基金面上项目(No.81473780,No.81774433)。
关键词
原发性失眠
功能磁共振
经皮耳穴电针
低频振荡振幅
比率低频振幅
局部一致性
爱泼沃斯思睡量表
Primary insomnia
Functional magnetic resonance imaging
Transcutaneous auricular electroacupuncture
Amplitude of low frequency fluctuation
Fractional amplitude of low frequency fluctuation
Regional homogeneity
Epworth sleepiness scale(ESS)
