摘要
目的:观察白花香莲解毒颗粒联合恩替卡韦分散片治疗乙型肝炎肝硬化代偿期的疗效。方法:选取乙型肝炎肝硬化代偿期患者60例,随机分为治疗组和对照组各30例,对照组给予恩替卡韦分散片治疗;治疗组给予白花香莲解毒颗粒联合恩替卡韦分散片治疗,两组均治疗48周。观察治疗后两组肝功能、HBV-DNA、肝纤四项水平及肝硬度值(LSM)的变化。结果:治疗后,两组血清HA、LN、IV-C、PC-Ⅲ水平与本组治疗前比较,差异均有统计学意义(P<0.05);治疗后,治疗组血清HA、LN、IV-C、PC-Ⅲ水平低于同期对照组,差异均有统计学意义(P<0.05);治疗后,治疗组在抑制HBV-DNA复制方面显著优于对照组(P<0.05);治疗后,两组的TBIL、AST、ALT水平均低于治疗前,且治疗组均优于对照组,差异均具有统计学意义(P<0.05)。结论:白花香莲解毒颗粒可以有效改善乙型肝炎肝硬化代偿期患者肝纤维化,抑制病毒复制,改善肝功能指标。
Objective To evaluate the efficacy of Baihua Xianglian Detoxification Granule combined with Entecavir Dispersible Tablets in the treatment of hepatitis B liver cirrhosis in the compensatory phase.Methods 60 patients with compensated hepatitis B cirrhosis were selected and randomly divided into treatment group and control group,30 cases in each group.The treatment group was given Baihualian Jiedu Granules combined with Entecavir dispersible tablets,while the control group was given Entecavir dispersible tablets.Both groups were treated for 48 weeks.The changes of liver function,HBV-DNA,liver fiber and liver hardness(LSM)in 2 groups were observed after treatment.Results after treatment,two groups of patients serum HA,LN,IV-C,PC-Ⅲlevels compared with before this treatment,difference have statistical significance(P<0.05);After treatment,the treatment group of serum HA,LN,IV-C,PC-Ⅲlevel lower than control group during this period,the difference had statistical significance(P<0.05);After treatment,the inhibition of HBV-DNA replication in the treatment group was significantly better than that in the control group(P<0.05);After treatment,the levels of TBIL,AST and ALT in 2 groups were lower than before treatment,and the treatment group was better than the control group,with statistical significance(P<0.05).Conclusion Baihualianjiedu granule can effectively improve liver fibrosis,inhibit virus replication and improve liver function index in patients with hepatitis B cirrhosis.
作者
邱华
李旺
舒发明
蒙荫杰
毛德文
QIU Hua;LI Wang;SHU Faming;MENG Yinjie;MAO Dewen(Department of Hepatology,the First Affiliated Hospital of Guangxi University of traditional Chinese Medicine,Nannning 530023,China;Graduate School of Guangxi University of traditional Chinese Medicine,Nanning 530001,China)
出处
《中国民族民间医药》
2021年第19期106-108,111,共4页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
广西中医肝病临床医学研究中心建设项目(桂科AD17129001)
国家自然科学基金项目(81660827,81860889)
中国博士后科学基金面上资助项目(2019M653312)
广西重点研发计划项目(2017AB45166)
广西自然科学基金资助项目(2020JJA140308)
第二批广西高层次骨干人才培养139计划(桂卫科教发[2018]22号)。
关键词
白花香莲解毒颗粒
恩替卡韦分散片
慢性乙型肝炎
肝硬化代偿期
临床疗效
Baihua Xianglian Detoxification Granule
Entecavir Dispersible Tablets
Chronic Hepatitis B
Compensatory Period of Liver Cirrhosis
Clinical Curative Effect
