摘要
目的探讨杞精解痉方热敷治疗肝肾阴虚型下睑张力增高型结膜松弛症的疗效。方法收集II级下睑张力增高型结膜松弛症患者112例(112只眼),随机分为4组,每组28例(28只眼)。中药热敷组(A组)予中药热敷治疗;单纯热敷组(B组)予单纯热敷治疗;中药热敷+人工泪液组(C组)予中药热敷及人工泪液点眼治疗;人工泪液组(D组)予人工泪液点眼治疗。共治疗6周。记录治疗前后眼表疾病指数(OSDI)评分、下睑缘压强(LEP)、泪液分泌试验(SIT)、泪膜破裂时间(BUT),并进行统计学分析。结果(1)OSDI评分:治疗前后比较,4组OSDI评分均下降(F_(A组)=29.594,F_(B组)=44.806,F_(C组)=47.254,均P=0.000;F_(D组)=7.232,P=0.003)。治疗后2周,中药热敷+人工泪液组OSDI评分低于人工泪液组(t=2.873,P=0.029);治疗后4周及6周,中药热敷组、单纯热敷组及中药热敷+人工泪液组OSDI评分均低于人工泪液组,均有统计学意义(P<0.05)。(2)LEP:治疗前后比较,除人工泪液组外,其他3组LEP值均下降(F_(A组)=205.023,F_(B组)=137.467,F_(C组)=247.253,均P=0.000)。治疗后4周及6周,中药热敷组、单纯热敷组及中药热敷+人工泪液组LEP值均低于人工泪液组,均有统计学意义(P<0.05)。(3)SIT:治疗前后比较,4组SIT差异均无统计学意义(P>0.05)。治疗后2、4、6周各组SIT差异均无统计学意义(P>0.05)。(4)BUT:治疗前后比较,4组BUT均升高(F_(A组)=37.281,F_(B组)=17.064,F_(C组)=27.293,均P=0.000;F_(D组)=6.682,P=0.003)。治疗后4周及6周,中药热敷组、中药热敷+人工泪液组BUT均高于单纯热敷组、人工泪液组,均有统计学意义(P<0.05)。结论杞精解痉方热敷能改善下睑张力增高型结膜松弛症患者眼表症状,并缓解睑缘高张力,提高泪膜稳定性,对无需手术的下睑张力增高型结膜松弛症患者有较好疗效。
OBJECTIVE To explore the curative effect of hot compress therapy with Qijing Jiejing powder on conjunctivochalasis with increased tension of lower eyelid in liver and kidney yin deficiency pattern.METHODS A total of 112 patients(112 eyes)with conjunctivochalasis(grade II)of increased tension of lower eyelid were randomly divided into four groups,28 eyes enrolled in each group.Hot compress with Traditional Chinese Medicine(TCM)group(Group A)was treated with Chinese medicine hot compress;Hot compress group(Group B)was treated with hot compress alone;Hot compress with TCM plus artificial tears group(Group C)received Chinese medicine hot compress and artificial tear treatment;Artificial tears group(Group D)was treated with artificial tear.The treatment lasted for six weeks.The OSDI,BUT,SIT and LEP were used as observation indexes and were tested before and after treatment.RESULTS(1)OSDI:Before and after treatment,the OSDI scores of four groups decreased(F_(A)=29.594,F_(B)=44.806,F_(C)=47.254,all P=0.000;F_(D)=7.232,P=0.003).Two weeks after treatment,the OSDI of group C was lower than that of group D(t=2.873,P=0.029);Four and six weeks after treatment,the OSDI scores of group A,group B and group C were lower than those of group D(P<0.05).(2)LEP:Before and after treatment,except for group D,the LEP of the other three groups decreased(F_(A)=205.023,F_(B)=137.467,F_(C)=247.253,all P=0.000).Four and six weeks after treatment,the LEP of group A,group B and group C was lower than group D(P<0.05).(3)SIT:Before and after treatment,there was no statistically significant variations of SIT in the four groups(P>0.05).Two,four and six weeks after treatment,there was no significant variations of SIT in each group(P>0.05).(4)BUT:Before and after treatment,BUT elevated in four groups(F_(A)=37.281,F_(B)=17.064,F_(C)=27.293,all P=0.000;F_(D)=6.682,P=0.003).Four and six weeks after treatment,The BUT of group A and group C were higher than those of group B and group D(P<0.05).CONCLUSIONS Qijing Jiejing powder hot compress significantly can improve the ocular surface symptom in patients with increased tension of lower eyelid conjunctivochalasis without surgery,relieve the high tension of eyelid margin and improve tear film stability.
作者
符之瑄
周欢明
王晗敏
许愿
池华博文
李青松
FU Zhixuan;ZHOU Huanming;WANG Hanmin(Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)
出处
《中国中医眼科杂志》
2021年第9期634-638,642,共6页
China Journal of Chinese Ophthalmology
基金
上海市卫生健康委员会卫生行业临床研究专项(20194Y0175)
上海中医药大学附属普陀医院人才培养计划—育英计划(2017218A)。
关键词
睑缘张力
压强检测仪
结膜松弛症
热敷
eyelid tension
tensiometer
conjunctivochalasis
hot compress
